A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose meta...

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Autores principales: Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
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spelling oai:doaj.org-article:4ccddec6eb3c494894508ff7177b76832021-12-02T17:31:39ZA MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism10.1038/s41467-020-14323-y2041-1723https://doaj.org/article/4ccddec6eb3c494894508ff7177b76832020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14323-yhttps://doaj.org/toc/2041-1723Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.Marta Pradas-JuniNils R. HansmeierJenny C. LinkElena SchmidtBjørk Ditlev LarsenPaul KlemmNicola MeolaHande TopelRute LoureiroInes DhaouadiChristoph A. KieferRobin SchwarzerSajjad KhaniMatteo OliverioMotoharu AwazawaPeter FrommoltJoerg HeerenLudger SchejaMarkus HeineChristoph DieterichHildegard BüningLing YangHaiming CaoDario F. De JesusRohit N. KulkarniBranko ZevnikSimon E. TröderUwe KnippschildPeter A. EdwardsRichard G. LeeMasayuki YamamotoIgor UlitskyEduardo Fernandez-RebolloThomas Q. de Aguiar VallimJan-Wilhelm KornfeldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marta Pradas-Juni
Nils R. Hansmeier
Jenny C. Link
Elena Schmidt
Bjørk Ditlev Larsen
Paul Klemm
Nicola Meola
Hande Topel
Rute Loureiro
Ines Dhaouadi
Christoph A. Kiefer
Robin Schwarzer
Sajjad Khani
Matteo Oliverio
Motoharu Awazawa
Peter Frommolt
Joerg Heeren
Ludger Scheja
Markus Heine
Christoph Dieterich
Hildegard Büning
Ling Yang
Haiming Cao
Dario F. De Jesus
Rohit N. Kulkarni
Branko Zevnik
Simon E. Tröder
Uwe Knippschild
Peter A. Edwards
Richard G. Lee
Masayuki Yamamoto
Igor Ulitsky
Eduardo Fernandez-Rebollo
Thomas Q. de Aguiar Vallim
Jan-Wilhelm Kornfeld
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
description Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.
format article
author Marta Pradas-Juni
Nils R. Hansmeier
Jenny C. Link
Elena Schmidt
Bjørk Ditlev Larsen
Paul Klemm
Nicola Meola
Hande Topel
Rute Loureiro
Ines Dhaouadi
Christoph A. Kiefer
Robin Schwarzer
Sajjad Khani
Matteo Oliverio
Motoharu Awazawa
Peter Frommolt
Joerg Heeren
Ludger Scheja
Markus Heine
Christoph Dieterich
Hildegard Büning
Ling Yang
Haiming Cao
Dario F. De Jesus
Rohit N. Kulkarni
Branko Zevnik
Simon E. Tröder
Uwe Knippschild
Peter A. Edwards
Richard G. Lee
Masayuki Yamamoto
Igor Ulitsky
Eduardo Fernandez-Rebollo
Thomas Q. de Aguiar Vallim
Jan-Wilhelm Kornfeld
author_facet Marta Pradas-Juni
Nils R. Hansmeier
Jenny C. Link
Elena Schmidt
Bjørk Ditlev Larsen
Paul Klemm
Nicola Meola
Hande Topel
Rute Loureiro
Ines Dhaouadi
Christoph A. Kiefer
Robin Schwarzer
Sajjad Khani
Matteo Oliverio
Motoharu Awazawa
Peter Frommolt
Joerg Heeren
Ludger Scheja
Markus Heine
Christoph Dieterich
Hildegard Büning
Ling Yang
Haiming Cao
Dario F. De Jesus
Rohit N. Kulkarni
Branko Zevnik
Simon E. Tröder
Uwe Knippschild
Peter A. Edwards
Richard G. Lee
Masayuki Yamamoto
Igor Ulitsky
Eduardo Fernandez-Rebollo
Thomas Q. de Aguiar Vallim
Jan-Wilhelm Kornfeld
author_sort Marta Pradas-Juni
title A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
title_short A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
title_full A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
title_fullStr A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
title_full_unstemmed A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
title_sort mafg-lncrna axis links systemic nutrient abundance to hepatic glucose metabolism
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
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