ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some mo...

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Autores principales:	Carlo Lombardi, MD, Riccardo Asero, MD, Diego Bagnasco, MD, Francesco Blasi, MD, Matteo Bonini, MD, Mario Bussi, MD, Rikki F. Canevari, MD, Giorgio Walter Canonica, MD, Paolo Castelnuovo, MD, Lorenzo Cecchi, MD, Lorenzo Cosmi, MD, Matteo Gelardi, MD, Enrico Heffler, MD, Luciana Indinnimeo, MD, Massimo Landi, MD, Amelia Licari, MD, Francesco Liotta, MD, Alberto Macchi, MD, Luca Malvezzi, MD, Gianluigi Marseglia, MD, Claudio Micheletto, MD, Antonino Musarra, MD, Diego Peroni, MD, Giorgio Piacentini, MD, Venerino Poletti, MD, Luca Richeldi, MD, Angela Santoni, MD, Michele Schiappoli, MD, Gianenrico Senna, MD, Adriano Vaghi, MD, Alberto Villani, MD, Giovanni Passalacqua, MD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nasal polyps CRSwNP Biological antibodies ARIA Personalized medicine Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4ccea6e57c304ff7bb0926fa46f35dac
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spelling	oai:doaj.org-article:4ccea6e57c304ff7bb0926fa46f35dac2021-11-12T04:30:13ZARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments1939-455110.1016/j.waojou.2021.100592https://doaj.org/article/4ccea6e57c304ff7bb0926fa46f35dac2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1939455121000867https://doaj.org/toc/1939-4551In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies for severe asthma were assessed also in polyposis, with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT, allergists), it was felt that an educational and informative document was needed to better identify the indications of biologicals in nasal polyposis. We collected the main Italian Scientific Societies, and prepared (under the Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all Societies, to provide a provisional statement for the future use of monoclonal antibodies as a medical treatment for polyposis. It is the first nationwide endorsed document on this aspect. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.Carlo Lombardi, MDRiccardo Asero, MDDiego Bagnasco, MDFrancesco Blasi, MDMatteo Bonini, MDMario Bussi, MDRikki F. Canevari, MDGiorgio Walter Canonica, MDPaolo Castelnuovo, MDLorenzo Cecchi, MDLorenzo Cosmi, MDMatteo Gelardi, MDEnrico Heffler, MDLuciana Indinnimeo, MDMassimo Landi, MDAmelia Licari, MDFrancesco Liotta, MDAlberto Macchi, MDLuca Malvezzi, MDGianluigi Marseglia, MDClaudio Micheletto, MDAntonino Musarra, MDDiego Peroni, MDGiorgio Piacentini, MDVenerino Poletti, MDLuca Richeldi, MDAngela Santoni, MDMichele Schiappoli, MDGianenrico Senna, MDAdriano Vaghi, MDAlberto Villani, MDGiovanni Passalacqua, MDElsevierarticleNasal polypsCRSwNPBiological antibodiesARIAPersonalized medicineImmunologic diseases. AllergyRC581-607ENWorld Allergy Organization Journal, Vol 14, Iss 10, Pp 100592- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nasal polyps CRSwNP Biological antibodies ARIA Personalized medicine Immunologic diseases. Allergy RC581-607
spellingShingle	Nasal polyps CRSwNP Biological antibodies ARIA Personalized medicine Immunologic diseases. Allergy RC581-607 Carlo Lombardi, MD Riccardo Asero, MD Diego Bagnasco, MD Francesco Blasi, MD Matteo Bonini, MD Mario Bussi, MD Rikki F. Canevari, MD Giorgio Walter Canonica, MD Paolo Castelnuovo, MD Lorenzo Cecchi, MD Lorenzo Cosmi, MD Matteo Gelardi, MD Enrico Heffler, MD Luciana Indinnimeo, MD Massimo Landi, MD Amelia Licari, MD Francesco Liotta, MD Alberto Macchi, MD Luca Malvezzi, MD Gianluigi Marseglia, MD Claudio Micheletto, MD Antonino Musarra, MD Diego Peroni, MD Giorgio Piacentini, MD Venerino Poletti, MD Luca Richeldi, MD Angela Santoni, MD Michele Schiappoli, MD Gianenrico Senna, MD Adriano Vaghi, MD Alberto Villani, MD Giovanni Passalacqua, MD ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
description	In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies for severe asthma were assessed also in polyposis, with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT, allergists), it was felt that an educational and informative document was needed to better identify the indications of biologicals in nasal polyposis. We collected the main Italian Scientific Societies, and prepared (under the Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all Societies, to provide a provisional statement for the future use of monoclonal antibodies as a medical treatment for polyposis. It is the first nationwide endorsed document on this aspect. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.
format	article
author	Carlo Lombardi, MD Riccardo Asero, MD Diego Bagnasco, MD Francesco Blasi, MD Matteo Bonini, MD Mario Bussi, MD Rikki F. Canevari, MD Giorgio Walter Canonica, MD Paolo Castelnuovo, MD Lorenzo Cecchi, MD Lorenzo Cosmi, MD Matteo Gelardi, MD Enrico Heffler, MD Luciana Indinnimeo, MD Massimo Landi, MD Amelia Licari, MD Francesco Liotta, MD Alberto Macchi, MD Luca Malvezzi, MD Gianluigi Marseglia, MD Claudio Micheletto, MD Antonino Musarra, MD Diego Peroni, MD Giorgio Piacentini, MD Venerino Poletti, MD Luca Richeldi, MD Angela Santoni, MD Michele Schiappoli, MD Gianenrico Senna, MD Adriano Vaghi, MD Alberto Villani, MD Giovanni Passalacqua, MD
author_facet	Carlo Lombardi, MD Riccardo Asero, MD Diego Bagnasco, MD Francesco Blasi, MD Matteo Bonini, MD Mario Bussi, MD Rikki F. Canevari, MD Giorgio Walter Canonica, MD Paolo Castelnuovo, MD Lorenzo Cecchi, MD Lorenzo Cosmi, MD Matteo Gelardi, MD Enrico Heffler, MD Luciana Indinnimeo, MD Massimo Landi, MD Amelia Licari, MD Francesco Liotta, MD Alberto Macchi, MD Luca Malvezzi, MD Gianluigi Marseglia, MD Claudio Micheletto, MD Antonino Musarra, MD Diego Peroni, MD Giorgio Piacentini, MD Venerino Poletti, MD Luca Richeldi, MD Angela Santoni, MD Michele Schiappoli, MD Gianenrico Senna, MD Adriano Vaghi, MD Alberto Villani, MD Giovanni Passalacqua, MD
author_sort	Carlo Lombardi, MD
title	ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
title_short	ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
title_full	ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
title_fullStr	ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
title_full_unstemmed	ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
title_sort	aria-italy multidisciplinary consensus on nasal polyposis and biological treatments
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4ccea6e57c304ff7bb0926fa46f35dac
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ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

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