Estrogen deficiency accelerates lumbar facet joints arthritis

Abstract Dramatic increase in the prevalence of lumbar facet joint (LFJ) arthritis in women around the age of menopause indicates a protective role for estrogen in LFJ arthritis. To date, there is no evidence for this indication and the mechanism of such an effect remains poorly understood. In this...

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Autores principales:	Hao Chen, Hai Zhu, Kai Zhang, Kangwu Chen, Huilin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4cceedc8ab164b618f75e6e4f9fed8f2
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spelling	oai:doaj.org-article:4cceedc8ab164b618f75e6e4f9fed8f22021-12-02T12:31:49ZEstrogen deficiency accelerates lumbar facet joints arthritis10.1038/s41598-017-01427-72045-2322https://doaj.org/article/4cceedc8ab164b618f75e6e4f9fed8f22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01427-7https://doaj.org/toc/2045-2322Abstract Dramatic increase in the prevalence of lumbar facet joint (LFJ) arthritis in women around the age of menopause indicates a protective role for estrogen in LFJ arthritis. To date, there is no evidence for this indication and the mechanism of such an effect remains poorly understood. In this study, ovariectomized (OVX) mice were used to mimic the estrogen-deficient status of post-menopausal women. Micro-CT and immunohistochemistry was employed to assess the morphological and molecular changes in ovariectomy-induced LFJ arthritis. The results show that the LFJ subchondral bone mass was significantly decreased in OVX mice, with increased cavities on the interface of the subchondral bone. Severe cartilage degradation was observed in ovariectomy-induced LFJ arthritis. Increased blood vessels and innervations were also found in degenerated LFJ, particularly in the subchondral bone area. 17β-Estradiol treatment efficiently suppressed LFJ subchondral bone turnover, markedly inhibited cartilage degradation, and increased blood vessel and nerve ending growth in degenerated LFJ in OVX mice. Our study reveals that estrogen is a key factor in regulating LFJ metabolism. Severe LFJ degeneration occurs when estrogen is absent in vivo. Collapsed subchondral bone may be the initiation of this process, and estrogen replacement therapy can effectively prevent degeneration of LFJ under estrogen-deficient conditions.Hao ChenHai ZhuKai ZhangKangwu ChenHuilin YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Chen Hai Zhu Kai Zhang Kangwu Chen Huilin Yang Estrogen deficiency accelerates lumbar facet joints arthritis
description	Abstract Dramatic increase in the prevalence of lumbar facet joint (LFJ) arthritis in women around the age of menopause indicates a protective role for estrogen in LFJ arthritis. To date, there is no evidence for this indication and the mechanism of such an effect remains poorly understood. In this study, ovariectomized (OVX) mice were used to mimic the estrogen-deficient status of post-menopausal women. Micro-CT and immunohistochemistry was employed to assess the morphological and molecular changes in ovariectomy-induced LFJ arthritis. The results show that the LFJ subchondral bone mass was significantly decreased in OVX mice, with increased cavities on the interface of the subchondral bone. Severe cartilage degradation was observed in ovariectomy-induced LFJ arthritis. Increased blood vessels and innervations were also found in degenerated LFJ, particularly in the subchondral bone area. 17β-Estradiol treatment efficiently suppressed LFJ subchondral bone turnover, markedly inhibited cartilage degradation, and increased blood vessel and nerve ending growth in degenerated LFJ in OVX mice. Our study reveals that estrogen is a key factor in regulating LFJ metabolism. Severe LFJ degeneration occurs when estrogen is absent in vivo. Collapsed subchondral bone may be the initiation of this process, and estrogen replacement therapy can effectively prevent degeneration of LFJ under estrogen-deficient conditions.
format	article
author	Hao Chen Hai Zhu Kai Zhang Kangwu Chen Huilin Yang
author_facet	Hao Chen Hai Zhu Kai Zhang Kangwu Chen Huilin Yang
author_sort	Hao Chen
title	Estrogen deficiency accelerates lumbar facet joints arthritis
title_short	Estrogen deficiency accelerates lumbar facet joints arthritis
title_full	Estrogen deficiency accelerates lumbar facet joints arthritis
title_fullStr	Estrogen deficiency accelerates lumbar facet joints arthritis
title_full_unstemmed	Estrogen deficiency accelerates lumbar facet joints arthritis
title_sort	estrogen deficiency accelerates lumbar facet joints arthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4cceedc8ab164b618f75e6e4f9fed8f2
work_keys_str_mv	AT haochen estrogendeficiencyaccelerateslumbarfacetjointsarthritis AT haizhu estrogendeficiencyaccelerateslumbarfacetjointsarthritis AT kaizhang estrogendeficiencyaccelerateslumbarfacetjointsarthritis AT kangwuchen estrogendeficiencyaccelerateslumbarfacetjointsarthritis AT huilinyang estrogendeficiencyaccelerateslumbarfacetjointsarthritis
_version_	1718394276318019584

Estrogen deficiency accelerates lumbar facet joints arthritis

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