To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast

Background: Breast cancer is the most common cancer in urban and second common in rural Indian women. In India, in spite of the best treatment available being given to the patients they lose their lives because of paucity of diagnostic aids and lack of an organized breast cancer screening program. E...

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Autores principales:	Anju Kansal, Gaurav Jaswal, Shreya Garg, Manraj Singh Kang, Hanuman Prasad Yadav, Raja Paramjeet Singh Banipal, Pardeep Garg, Taranjeet Kaur
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	breast carcinoma positron emission tomography-computerized tomography Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/4cd05c40fe1e4516b40ad325a3d2b7aa
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spelling	oai:doaj.org-article:4cd05c40fe1e4516b40ad325a3d2b7aa2021-11-19T12:15:53ZTo evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast0975-740610.4103/jpbs.jpbs_163_21https://doaj.org/article/4cd05c40fe1e4516b40ad325a3d2b7aa2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1354;epage=1359;aulast=Kansalhttps://doaj.org/toc/0975-7406Background: Breast cancer is the most common cancer in urban and second common in rural Indian women. In India, in spite of the best treatment available being given to the patients they lose their lives because of paucity of diagnostic aids and lack of an organized breast cancer screening program. Early detection, accurate staging, and initiation of appropriate therapy are the key factors for improving the treatment outcome and prognosis of the disease for the patients. Traditional staging methods include clinical examination, blood tests, chest X-ray, ultrasound of the abdomen, and/or skeletal survey. As these tests lack sensitivity and specificity, these are being scaled down. The hybrid positron emission tomography-computerized tomography (PET-CT) is a unique tool in the field of imaging modalities that combines the effectiveness of PET and CT. This study was undertaken to assess the efficacy and accuracy of PET-CT as a single-session staging modality in the very initial stage itself and if it can replace the conventional means of staging. Methods: This was a cross-sectional study conducted in the Radiotherapy department at GGS Medical College and Hospital Faridkot from March 2014 to October 2015. 52 patients with newly diagnosed and histopathologically proven carcinoma breast were staged by conventional modalities (clinical examination, blood tests, X-ray chest, mammography, ultrasonography abdomen, skeletal survey) and by 18F-fluorodeoxyglucose (18F FDG) PET/CT. PET-CT images were used for the detection, localization, staging of tumors and detection, evaluation, and diagnosis of metastatic lesions, disease burden and organ function along with treatment planning and planning therapeutic procedures. Following the completion of initial study, the results of 18F FDG PET-CT staging in comparison with conventional staging method were assessed. Along with this, the accuracy, changes in staging of cases of carcinoma breast and cost-effectiveness of 18F-FDG PET-CT were also studied. Results: All the pathologic entities identified by conventional imaging were also perceived with 18F-FDG PET/CT. Therefore, we recommend the use of PET/CT as an important imaging modality for initial diagnosis of carcinoma breast.Anju KansalGaurav JaswalShreya GargManraj Singh KangHanuman Prasad YadavRaja Paramjeet Singh BanipalPardeep GargTaranjeet KaurWolters Kluwer Medknow Publicationsarticlebreastcarcinomapositron emission tomography-computerized tomographyPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1354-1359 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast carcinoma positron emission tomography-computerized tomography Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	breast carcinoma positron emission tomography-computerized tomography Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Anju Kansal Gaurav Jaswal Shreya Garg Manraj Singh Kang Hanuman Prasad Yadav Raja Paramjeet Singh Banipal Pardeep Garg Taranjeet Kaur To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
description	Background: Breast cancer is the most common cancer in urban and second common in rural Indian women. In India, in spite of the best treatment available being given to the patients they lose their lives because of paucity of diagnostic aids and lack of an organized breast cancer screening program. Early detection, accurate staging, and initiation of appropriate therapy are the key factors for improving the treatment outcome and prognosis of the disease for the patients. Traditional staging methods include clinical examination, blood tests, chest X-ray, ultrasound of the abdomen, and/or skeletal survey. As these tests lack sensitivity and specificity, these are being scaled down. The hybrid positron emission tomography-computerized tomography (PET-CT) is a unique tool in the field of imaging modalities that combines the effectiveness of PET and CT. This study was undertaken to assess the efficacy and accuracy of PET-CT as a single-session staging modality in the very initial stage itself and if it can replace the conventional means of staging. Methods: This was a cross-sectional study conducted in the Radiotherapy department at GGS Medical College and Hospital Faridkot from March 2014 to October 2015. 52 patients with newly diagnosed and histopathologically proven carcinoma breast were staged by conventional modalities (clinical examination, blood tests, X-ray chest, mammography, ultrasonography abdomen, skeletal survey) and by 18F-fluorodeoxyglucose (18F FDG) PET/CT. PET-CT images were used for the detection, localization, staging of tumors and detection, evaluation, and diagnosis of metastatic lesions, disease burden and organ function along with treatment planning and planning therapeutic procedures. Following the completion of initial study, the results of 18F FDG PET-CT staging in comparison with conventional staging method were assessed. Along with this, the accuracy, changes in staging of cases of carcinoma breast and cost-effectiveness of 18F-FDG PET-CT were also studied. Results: All the pathologic entities identified by conventional imaging were also perceived with 18F-FDG PET/CT. Therefore, we recommend the use of PET/CT as an important imaging modality for initial diagnosis of carcinoma breast.
format	article
author	Anju Kansal Gaurav Jaswal Shreya Garg Manraj Singh Kang Hanuman Prasad Yadav Raja Paramjeet Singh Banipal Pardeep Garg Taranjeet Kaur
author_facet	Anju Kansal Gaurav Jaswal Shreya Garg Manraj Singh Kang Hanuman Prasad Yadav Raja Paramjeet Singh Banipal Pardeep Garg Taranjeet Kaur
author_sort	Anju Kansal
title	To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
title_short	To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
title_full	To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
title_fullStr	To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
title_full_unstemmed	To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
title_sort	to evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/4cd05c40fe1e4516b40ad325a3d2b7aa
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To evaluate the role of positron emission tomography-computerized tomography in initial staging of carcinoma breast

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