Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.

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Detalles Bibliográficos
Autores principales: Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b
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Descripción
Sumario:hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.

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