Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.

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Autores principales:	Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b
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spelling	oai:doaj.org-article:4cd3936d370a4ba1b02244ee053db93b2021-12-02T14:42:32ZVascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina10.1038/s41467-020-14764-52041-1723https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14764-5https://doaj.org/toc/2041-1723hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.Tea Soon ParkLudovic ZimmerlinRebecca Evans-MosesJustin ThomasJeffrey S. HuoRiya KanherkarAlice HeNensi RuzgarRhonda GrebeImran BhuttoMichael BarbatoMichael A. KoldobskiyGerard LuttyElias T. ZambidisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tea Soon Park Ludovic Zimmerlin Rebecca Evans-Moses Justin Thomas Jeffrey S. Huo Riya Kanherkar Alice He Nensi Ruzgar Rhonda Grebe Imran Bhutto Michael Barbato Michael A. Koldobskiy Gerard Lutty Elias T. Zambidis Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
description	hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.
format	article
author	Tea Soon Park Ludovic Zimmerlin Rebecca Evans-Moses Justin Thomas Jeffrey S. Huo Riya Kanherkar Alice He Nensi Ruzgar Rhonda Grebe Imran Bhutto Michael Barbato Michael A. Koldobskiy Gerard Lutty Elias T. Zambidis
author_facet	Tea Soon Park Ludovic Zimmerlin Rebecca Evans-Moses Justin Thomas Jeffrey S. Huo Riya Kanherkar Alice He Nensi Ruzgar Rhonda Grebe Imran Bhutto Michael Barbato Michael A. Koldobskiy Gerard Lutty Elias T. Zambidis
author_sort	Tea Soon Park
title	Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
title_short	Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
title_full	Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
title_fullStr	Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
title_full_unstemmed	Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
title_sort	vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human ipsc potentiate efficient revascularization of ischemic retina
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b
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Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina

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