Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss

Abstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the con...

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Autores principales:	Ka Ying Bonnie Ng, George Cherian, Alexandra J. Kermack, Sarah Bailey, Nick Macklon, Sesh K. Sunkara, Ying Cheong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4cd8dc42df55485696f212b331f0a04f
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spelling	oai:doaj.org-article:4cd8dc42df55485696f212b331f0a04f2021-12-02T18:18:06ZSystematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss10.1038/s41598-021-86445-22045-2322https://doaj.org/article/4cd8dc42df55485696f212b331f0a04f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86445-2https://doaj.org/toc/2045-2322Abstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed.Ka Ying Bonnie NgGeorge CherianAlexandra J. KermackSarah BaileyNick MacklonSesh K. SunkaraYing CheongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
description	Abstract It is known that lifestyle factors affect sporadic miscarriage, but the extent of this on RPL (recurrent pregnancy loss) is less well known. A systematic review and meta-analysis was performed to assess the associations between lifestyle factors and RPL. Studies that analysed RPL in the context of BMI, smoking, alcohol and caffeine intake were included. The primary and secondary outcomes were odds of having RPL in the general population and odds of further miscarriage, respectively. Underweight and women with BMI > 25 are at higher odds of RPL in the general population (OR 1.2, 95% CI 1.12–1.28 and OR 1.21, 95% CI 1.06–1.38, respectively). In women with RPL, having BMI > 30 and BMI > 25 has increased odds of further miscarriages (OR 1.77, 95% CI 1.25–2.50 and OR 1.35, 95% CI 1.07–1.72, respectively). The quality of the evidence for our findings was low or very low. Being underweight and BMI > 25 contributes significantly to increased risk of RPL (general population). BMI > 25 or BMI > 30 increases the risk of further miscarriages (RPL population). Larger studies addressing the effects of alcohol, cigarette smoking and caffeine on the risk of RPL with optimisation of BMI in this cohort of women are now needed.
format	article
author	Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong
author_facet	Ka Ying Bonnie Ng George Cherian Alexandra J. Kermack Sarah Bailey Nick Macklon Sesh K. Sunkara Ying Cheong
author_sort	Ka Ying Bonnie Ng
title	Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
title_short	Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
title_full	Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
title_fullStr	Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
title_full_unstemmed	Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
title_sort	systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4cd8dc42df55485696f212b331f0a04f
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Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss

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