mTORC1 accelerates retinal development via the immunoproteasome

One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enha...

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Autores principales:	Ji-Heon Choi, Hong Seok Jo, Soyeon Lim, Hyoung-Tai Kim, Kang Woo Lee, Kyeong Hwan Moon, Taejeong Ha, Sang Soo Kwak, Yeha Kim, Eun Jung Lee, Cheol O. Joe, Jin Woo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cdc58e73baf4679a3cf8a1bc28ef883
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:4cdc58e73baf4679a3cf8a1bc28ef8832021-12-02T14:39:45ZmTORC1 accelerates retinal development via the immunoproteasome10.1038/s41467-018-04774-92041-1723https://doaj.org/article/4cdc58e73baf4679a3cf8a1bc28ef8832018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04774-9https://doaj.org/toc/2041-1723One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enhances the degradation of cyclins.Ji-Heon ChoiHong Seok JoSoyeon LimHyoung-Tai KimKang Woo LeeKyeong Hwan MoonTaejeong HaSang Soo KwakYeha KimEun Jung LeeCheol O. JoeJin Woo KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Heon Choi Hong Seok Jo Soyeon Lim Hyoung-Tai Kim Kang Woo Lee Kyeong Hwan Moon Taejeong Ha Sang Soo Kwak Yeha Kim Eun Jung Lee Cheol O. Joe Jin Woo Kim mTORC1 accelerates retinal development via the immunoproteasome
description	One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enhances the degradation of cyclins.
format	article
author	Ji-Heon Choi Hong Seok Jo Soyeon Lim Hyoung-Tai Kim Kang Woo Lee Kyeong Hwan Moon Taejeong Ha Sang Soo Kwak Yeha Kim Eun Jung Lee Cheol O. Joe Jin Woo Kim
author_facet	Ji-Heon Choi Hong Seok Jo Soyeon Lim Hyoung-Tai Kim Kang Woo Lee Kyeong Hwan Moon Taejeong Ha Sang Soo Kwak Yeha Kim Eun Jung Lee Cheol O. Joe Jin Woo Kim
author_sort	Ji-Heon Choi
title	mTORC1 accelerates retinal development via the immunoproteasome
title_short	mTORC1 accelerates retinal development via the immunoproteasome
title_full	mTORC1 accelerates retinal development via the immunoproteasome
title_fullStr	mTORC1 accelerates retinal development via the immunoproteasome
title_full_unstemmed	mTORC1 accelerates retinal development via the immunoproteasome
title_sort	mtorc1 accelerates retinal development via the immunoproteasome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4cdc58e73baf4679a3cf8a1bc28ef883
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mTORC1 accelerates retinal development via the immunoproteasome

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