Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.

<h4>Background</h4>Individuals with anorexia nervosa (AN) are often cognitively rigid and behaviorally over-controlled. We previously showed that adult females recovered from AN relative to healthy comparison females had less prefrontal activation during an inhibition task, which suggest...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christina Wierenga, Amanda Bischoff-Grethe, A James Melrose, Emily Grenesko-Stevens, Zoë Irvine, Angela Wagner, Alan Simmons, Scott Matthews, Wai-Ying Wendy Yau, Christine Fennema-Notestine, Walter H Kaye
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4ce5a94ba2e1488b9513034b7a06c9a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4ce5a94ba2e1488b9513034b7a06c9a2
record_format	dspace
spelling	oai:doaj.org-article:4ce5a94ba2e1488b9513034b7a06c9a22021-11-18T08:26:56ZAltered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.1932-620310.1371/journal.pone.0092017https://doaj.org/article/4ce5a94ba2e1488b9513034b7a06c9a22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651705/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Individuals with anorexia nervosa (AN) are often cognitively rigid and behaviorally over-controlled. We previously showed that adult females recovered from AN relative to healthy comparison females had less prefrontal activation during an inhibition task, which suggested a functional brain correlate of altered inhibitory processing in individuals recovered from AN. However, the degree to which these functional brain alterations are related to disease state and whether error processing is altered in AN individuals is unknown.<h4>Methodology/principal findings</h4>In the current study, ill adolescent AN females (n = 11) and matched healthy comparison adolescents (CA) with no history of an eating disorder (n = 12) performed a validated stop signal task (SST) during functional magnetic resonance imaging (fMRI) to explore differences in error and inhibitory processing. The groups did not differ on sociodemographic variables or on SST performance. During inhibitory processing, a significant group x difficulty (hard, easy) interaction was detected in the right dorsal anterior cingulate cortex (ACC), right middle frontal gyrus (MFG), and left posterior cingulate cortex (PCC), which was characterized by less activation in AN compared to CA participants during hard trials. During error processing, a significant group x accuracy (successful inhibit, failed inhibit) interaction in bilateral MFG and right PCC was observed, which was characterized by less activation in AN compared to CA participants during error (i.e., failed inhibit) trials.<h4>Conclusion/significance</h4>Consistent with our prior findings in recovered AN, ill AN adolescents, relative to CA, showed less inhibition-related activation within the dorsal ACC, MFG and PCC as inhibitory demand increased. In addition, ill AN adolescents, relative to CA, also showed reduced activation to errors in the bilateral MFG and left PCC. These findings suggest that altered prefrontal and cingulate activation during inhibitory and error processing may represent a behavioral characteristic in AN that is independent of the state of recovery.Christina WierengaAmanda Bischoff-GretheA James MelroseEmily Grenesko-StevensZoë IrvineAngela WagnerAlan SimmonsScott MatthewsWai-Ying Wendy YauChristine Fennema-NotestineWalter H KayePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e92017 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina Wierenga Amanda Bischoff-Grethe A James Melrose Emily Grenesko-Stevens Zoë Irvine Angela Wagner Alan Simmons Scott Matthews Wai-Ying Wendy Yau Christine Fennema-Notestine Walter H Kaye Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
description	<h4>Background</h4>Individuals with anorexia nervosa (AN) are often cognitively rigid and behaviorally over-controlled. We previously showed that adult females recovered from AN relative to healthy comparison females had less prefrontal activation during an inhibition task, which suggested a functional brain correlate of altered inhibitory processing in individuals recovered from AN. However, the degree to which these functional brain alterations are related to disease state and whether error processing is altered in AN individuals is unknown.<h4>Methodology/principal findings</h4>In the current study, ill adolescent AN females (n = 11) and matched healthy comparison adolescents (CA) with no history of an eating disorder (n = 12) performed a validated stop signal task (SST) during functional magnetic resonance imaging (fMRI) to explore differences in error and inhibitory processing. The groups did not differ on sociodemographic variables or on SST performance. During inhibitory processing, a significant group x difficulty (hard, easy) interaction was detected in the right dorsal anterior cingulate cortex (ACC), right middle frontal gyrus (MFG), and left posterior cingulate cortex (PCC), which was characterized by less activation in AN compared to CA participants during hard trials. During error processing, a significant group x accuracy (successful inhibit, failed inhibit) interaction in bilateral MFG and right PCC was observed, which was characterized by less activation in AN compared to CA participants during error (i.e., failed inhibit) trials.<h4>Conclusion/significance</h4>Consistent with our prior findings in recovered AN, ill AN adolescents, relative to CA, showed less inhibition-related activation within the dorsal ACC, MFG and PCC as inhibitory demand increased. In addition, ill AN adolescents, relative to CA, also showed reduced activation to errors in the bilateral MFG and left PCC. These findings suggest that altered prefrontal and cingulate activation during inhibitory and error processing may represent a behavioral characteristic in AN that is independent of the state of recovery.
format	article
author	Christina Wierenga Amanda Bischoff-Grethe A James Melrose Emily Grenesko-Stevens Zoë Irvine Angela Wagner Alan Simmons Scott Matthews Wai-Ying Wendy Yau Christine Fennema-Notestine Walter H Kaye
author_facet	Christina Wierenga Amanda Bischoff-Grethe A James Melrose Emily Grenesko-Stevens Zoë Irvine Angela Wagner Alan Simmons Scott Matthews Wai-Ying Wendy Yau Christine Fennema-Notestine Walter H Kaye
author_sort	Christina Wierenga
title	Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
title_short	Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
title_full	Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
title_fullStr	Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
title_full_unstemmed	Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.
title_sort	altered bold response during inhibitory and error processing in adolescents with anorexia nervosa.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4ce5a94ba2e1488b9513034b7a06c9a2
work_keys_str_mv	AT christinawierenga alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT amandabischoffgrethe alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT ajamesmelrose alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT emilygreneskostevens alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT zoeirvine alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT angelawagner alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT alansimmons alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT scottmatthews alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT waiyingwendyyau alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT christinefennemanotestine alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa AT walterhkaye alteredboldresponseduringinhibitoryanderrorprocessinginadolescentswithanorexianervosa
_version_	1718421799589380096

Altered BOLD response during inhibitory and error processing in adolescents with anorexia nervosa.

Ejemplares similares