Developmental nonlinearity drives phenotypic robustness

Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effe...

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Main Authors:	Rebecca M. Green, Jennifer L. Fish, Nathan M. Young, Francis J. Smith, Benjamin Roberts, Katie Dolan, Irene Choi, Courtney L. Leach, Paul Gordon, James M. Cheverud, Charles C. Roseman, Trevor J. Williams, Ralph S. Marcucio, Benedikt Hallgrímsson
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/4cead5cb41ca4d3196d3cbf94d5c65c2
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spelling	oai:doaj.org-article:4cead5cb41ca4d3196d3cbf94d5c65c22021-12-02T17:01:24ZDevelopmental nonlinearity drives phenotypic robustness10.1038/s41467-017-02037-72041-1723https://doaj.org/article/4cead5cb41ca4d3196d3cbf94d5c65c22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02037-7https://doaj.org/toc/2041-1723Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effect of Fgf8 expression.Rebecca M. GreenJennifer L. FishNathan M. YoungFrancis J. SmithBenjamin RobertsKatie DolanIrene ChoiCourtney L. LeachPaul GordonJames M. CheverudCharles C. RosemanTrevor J. WilliamsRalph S. MarcucioBenedikt HallgrímssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson Developmental nonlinearity drives phenotypic robustness
description	Developmental processes often involve nonlinearities, but the consequences for translating genotype to phenotype are not well characterized. Here, Green et al. vary Fgf8 signaling across allelic series of mice and show that phenotypic robustness in craniofacial shape is explained by a nonlinear effect of Fgf8 expression.
format	article
author	Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson
author_facet	Rebecca M. Green Jennifer L. Fish Nathan M. Young Francis J. Smith Benjamin Roberts Katie Dolan Irene Choi Courtney L. Leach Paul Gordon James M. Cheverud Charles C. Roseman Trevor J. Williams Ralph S. Marcucio Benedikt Hallgrímsson
author_sort	Rebecca M. Green
title	Developmental nonlinearity drives phenotypic robustness
title_short	Developmental nonlinearity drives phenotypic robustness
title_full	Developmental nonlinearity drives phenotypic robustness
title_fullStr	Developmental nonlinearity drives phenotypic robustness
title_full_unstemmed	Developmental nonlinearity drives phenotypic robustness
title_sort	developmental nonlinearity drives phenotypic robustness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4cead5cb41ca4d3196d3cbf94d5c65c2
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Developmental nonlinearity drives phenotypic robustness

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