CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset

CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset

Abstract The role of cytochrome P450 drug metabolizing enzymes in the efficacy of tamoxifen treatment of breast cancer is subject to substantial interest and controversy. CYP2D6 have been intensively studied, but the role of CYP2C19 is less elucidated, and we studied the association of CYPC19 genoty...

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Autores principales: Per Damkier, Anders Kjærsgaard, Kimberly A. Barker, Deidre Cronin-Fenton, Anatasha Crawford, Ylva Hellberg, Emilius A. M. Janssen, Carl Langefeld, Thomas P. Ahern, Timothy L. Lash
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/4ceb888b86f14d59982b5e5a3175cd15
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