Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus

The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patient...

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Autores principales:	Łukasz Zapała, Michał Kunc, Sumit Sharma, Wojciech Biernat, Piotr Radziszewski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	renal tumor tumor thrombus radical nephrectomy prognostic factors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4cec4958dd95458d87df79b8c8eb2929
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spelling	oai:doaj.org-article:4cec4958dd95458d87df79b8c8eb29292021-11-25T17:22:09ZLow Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus10.3390/diagnostics111121592075-4418https://doaj.org/article/4cec4958dd95458d87df79b8c8eb29292021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2159https://doaj.org/toc/2075-4418The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012–2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35.3 months). The association between lower LMR and the presence of tumor necrosis (<i>p</i> = 0.0004) was observed. Amongst systemic inflammatory markers, only LMR was selected as the sensitive marker predicting death with a calculated cut-off value of 2.53. OS was decreased in patients presenting with low LMR when compared to the high LMR group (39% vs. 82%, <i>p</i> = 0.0011). Neither NLR nor PLR were associated with survival rates. In multivariate analysis, LMR was identified as the independent prognostic factor (HR = 0.20, 95% CI 0.07–0.55, <i>p</i> = 0.001). Low values of LMR (<2.53) are independently connected with poorer OS in patients with RCC and coexisting tumor thrombus. The incorporation of the hematological variables into the prognostic model greatly increased its accuracy in predicting survival in the distinctive subpopulation of patients with RCC.Łukasz ZapałaMichał KuncSumit SharmaWojciech BiernatPiotr RadziszewskiMDPI AGarticlerenal tumortumor thrombusradical nephrectomyprognostic factorsMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2159, p 2159 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal tumor tumor thrombus radical nephrectomy prognostic factors Medicine (General) R5-920
spellingShingle	renal tumor tumor thrombus radical nephrectomy prognostic factors Medicine (General) R5-920 Łukasz Zapała Michał Kunc Sumit Sharma Wojciech Biernat Piotr Radziszewski Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
description	The purpose of the study was to determine the influence of lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) values on the prognosis in patients with renal cell carcinoma (RCC) and venous tumor thrombus. The respective data of 91 patients treated with radical surgery in the years 2012–2021 in 2 tertiary referral urological centers were retrieved from local medical databases. Mean calculated 3-year overall survival (OS) reached 70% (mean follow-up 35.3 months). The association between lower LMR and the presence of tumor necrosis (<i>p</i> = 0.0004) was observed. Amongst systemic inflammatory markers, only LMR was selected as the sensitive marker predicting death with a calculated cut-off value of 2.53. OS was decreased in patients presenting with low LMR when compared to the high LMR group (39% vs. 82%, <i>p</i> = 0.0011). Neither NLR nor PLR were associated with survival rates. In multivariate analysis, LMR was identified as the independent prognostic factor (HR = 0.20, 95% CI 0.07–0.55, <i>p</i> = 0.001). Low values of LMR (<2.53) are independently connected with poorer OS in patients with RCC and coexisting tumor thrombus. The incorporation of the hematological variables into the prognostic model greatly increased its accuracy in predicting survival in the distinctive subpopulation of patients with RCC.
format	article
author	Łukasz Zapała Michał Kunc Sumit Sharma Wojciech Biernat Piotr Radziszewski
author_facet	Łukasz Zapała Michał Kunc Sumit Sharma Wojciech Biernat Piotr Radziszewski
author_sort	Łukasz Zapała
title	Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_short	Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_full	Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_fullStr	Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_full_unstemmed	Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus
title_sort	low lymphocyte-to-monocyte ratio is the potential indicator of worse overall survival in patients with renal cell carcinoma and venous tumor thrombus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4cec4958dd95458d87df79b8c8eb2929
work_keys_str_mv	AT łukaszzapała lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus AT michałkunc lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus AT sumitsharma lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus AT wojciechbiernat lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus AT piotrradziszewski lowlymphocytetomonocyteratioisthepotentialindicatorofworseoverallsurvivalinpatientswithrenalcellcarcinomaandvenoustumorthrombus
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Low Lymphocyte-to-Monocyte Ratio Is the Potential Indicator of Worse Overall Survival in Patients with Renal Cell Carcinoma and Venous Tumor Thrombus

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