Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

Abstract Background Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no re...

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Main Authors: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen, Shuei-Liong Lin
Format: article
Language:EN
Published: BMC 2021
Subjects:
Erythropoietin
Hypoxia-inducible factor 2α
Pericyte
Transforming growth factor-β1
Medicine
R
Online Access:https://doaj.org/article/4cecab6670294871beec1077d0bd73b3
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https://doaj.org/article/4cecab6670294871beec1077d0bd73b3

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