Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects

Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects

Saud A Alanazi, Yousef S Badawood, Mohammed A Aldawood, Gamal A El-Hiti, Ali M MasmaliCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi ArabiaPurpose: To evaluate the tear ferning patterns in dry eye and normal eye subject...

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Autores principales: Alanazi SA, Badawood YS, Aldawood MA, El-Hiti GA, Masmali AM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
dry eye
eye drops
tear film
tear meniscus height
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/4cfbbc65092e4292b023aad7443eee46
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spelling oai:doaj.org-article:4cfbbc65092e4292b023aad7443eee462021-12-02T06:35:55ZEffect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects1177-5483https://doaj.org/article/4cfbbc65092e4292b023aad7443eee462019-06-01T00:00:00Zhttps://www.dovepress.com/effect-of-refresh-plusreg-preservative-free-lubricant-eyedrops-on-tear-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Saud A Alanazi, Yousef S Badawood, Mohammed A Aldawood, Gamal A El-Hiti, Ali M MasmaliCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi ArabiaPurpose: To evaluate the tear ferning patterns in dry eye and normal eye subjects in the 3 hours following application of Refresh Plus® preservative-free lubricant eyedrops.Methods: Thirty men with dry eye (mean age 22.14±2.34 years) and 30 age-matched men with normal eyes (mean age 23.91±3.24 years) were enrolled. Eyes were classified as normal or dry based on their Ocular Surface Disease Index score, tear meniscus height, and noninvasive tear breakup time. The tear ferning test was performed before and 30, 60, 120, and 180 minutes after application of a Refresh Plus eyedrop into the right eye in each subject.Results: There was a significant change in tear ferning grade after application of Refresh Plus eyedrops (P=0.02, Wilcoxon test) in the group with dry eye, but not in the normal eye group (P=0.19, Wilcoxon test). The correlation of tear ferning grade was moderate (r=0.484, P=0.049) at 60 minutes after application of the eyedrops and strong at 120 minutes (r=0.560, P=0.019) and 180 minutes (r=0.726, P=0.001). There was also a strong correlation (r=0.865, P=0.001) between tear ferning grades obtained 120 and 180 minutes after application. In the normal eye group, there was a moderate (r=0.407, P=0.029) correlation between tear ferning grades obtained before and 60 minutes after application of the eyedrops. There was also a strong correlation (r=0.532, P=0.003) between tear ferning grades obtained 120 and 180 minutes after application.Conclusion: Tear ferning patterns improved significantly after application of Refresh Plus preservative-free lubricant eyedrops in subjects with dry eye. Artificial tears containing sodium carboxymethylcellulose, such as Refresh Plus, can be used to improve tear ferning patterns in dry eye for at least 3 hours.Keywords: dry eye, eyedrops, tear film, tear meniscus heightAlanazi SABadawood YSAldawood MAEl-Hiti GAMasmali AMDove Medical Pressarticledry eyeeye dropstear filmtear meniscus heightOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1011-1017 (2019)
institution DOAJ
collection DOAJ
language EN
topic dry eye
eye drops
tear film
tear meniscus height
Ophthalmology
RE1-994
spellingShingle dry eye
eye drops
tear film
tear meniscus height
Ophthalmology
RE1-994
Alanazi SA
Badawood YS
Aldawood MA
El-Hiti GA
Masmali AM
Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
description Saud A Alanazi, Yousef S Badawood, Mohammed A Aldawood, Gamal A El-Hiti, Ali M MasmaliCornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi ArabiaPurpose: To evaluate the tear ferning patterns in dry eye and normal eye subjects in the 3 hours following application of Refresh Plus® preservative-free lubricant eyedrops.Methods: Thirty men with dry eye (mean age 22.14±2.34 years) and 30 age-matched men with normal eyes (mean age 23.91±3.24 years) were enrolled. Eyes were classified as normal or dry based on their Ocular Surface Disease Index score, tear meniscus height, and noninvasive tear breakup time. The tear ferning test was performed before and 30, 60, 120, and 180 minutes after application of a Refresh Plus eyedrop into the right eye in each subject.Results: There was a significant change in tear ferning grade after application of Refresh Plus eyedrops (P=0.02, Wilcoxon test) in the group with dry eye, but not in the normal eye group (P=0.19, Wilcoxon test). The correlation of tear ferning grade was moderate (r=0.484, P=0.049) at 60 minutes after application of the eyedrops and strong at 120 minutes (r=0.560, P=0.019) and 180 minutes (r=0.726, P=0.001). There was also a strong correlation (r=0.865, P=0.001) between tear ferning grades obtained 120 and 180 minutes after application. In the normal eye group, there was a moderate (r=0.407, P=0.029) correlation between tear ferning grades obtained before and 60 minutes after application of the eyedrops. There was also a strong correlation (r=0.532, P=0.003) between tear ferning grades obtained 120 and 180 minutes after application.Conclusion: Tear ferning patterns improved significantly after application of Refresh Plus preservative-free lubricant eyedrops in subjects with dry eye. Artificial tears containing sodium carboxymethylcellulose, such as Refresh Plus, can be used to improve tear ferning patterns in dry eye for at least 3 hours.Keywords: dry eye, eyedrops, tear film, tear meniscus height
format article
author Alanazi SA
Badawood YS
Aldawood MA
El-Hiti GA
Masmali AM
author_facet Alanazi SA
Badawood YS
Aldawood MA
El-Hiti GA
Masmali AM
author_sort Alanazi SA
title Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
title_short Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
title_full Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
title_fullStr Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
title_full_unstemmed Effect of Refresh Plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
title_sort effect of refresh plus® preservative-free lubricant eyedrops on tear ferning patterns in dry eye and normal eye subjects
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/4cfbbc65092e4292b023aad7443eee46
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