Medications that cause weight gain and alternatives in Canada: a narrative review

Sean Wharton,1,2 Lilian Raiber,1 Kristin J Serodio,1 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Toronto, Canada; 2School of Kinesiology and Health Science, York University, Toronto, Canada Background: The cause of the obesity epidemic is multifactorial, but may, in part, be r...

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Autores principales:	Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RAG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	weight gain weight loss weight neutral adverse effects of medications obesity adjunctive therapy Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4cfe91e75fd34c9fb3a80152c7c6e196
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spelling	oai:doaj.org-article:4cfe91e75fd34c9fb3a80152c7c6e1962021-12-02T08:06:43ZMedications that cause weight gain and alternatives in Canada: a narrative review1178-7007https://doaj.org/article/4cfe91e75fd34c9fb3a80152c7c6e1962018-08-01T00:00:00Zhttps://www.dovepress.com/medications-that-cause-weight-gain-and-alternatives-in-canada-a-narrat-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sean Wharton,1,2 Lilian Raiber,1 Kristin J Serodio,1 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Toronto, Canada; 2School of Kinesiology and Health Science, York University, Toronto, Canada Background: The cause of the obesity epidemic is multifactorial, but may, in part, be related to medication-induced weight gain. While clinicians may strive to do their best to select pharmacotherapy(ies) that has the least negative impact on weight, the literature regarding the weight effects of medication is often limited and devoid of alternative therapies. Results: Antipsychotics, antidepressants, antihyperglycemics, antihypertensives and corticosteroids all contain medications that were associated with significant weight gain. However, there are several medication alternatives within the majority of these classes associated with weight neutral or even weight loss effects. Further, while not all of the classes of medication examined in this review have weight-favorable alternatives, there exist many other tools to mitigate weight gain associated with medication use, such as changes in dosing, medication delivery or the use of adjunctive therapies. Conclusion: Medication-induced weight gain can be frustrating for both the patient and the clinician. As the use of pharmaceuticals continues to increase, it is pertinent for clinicians to consider the weight effects of medications prior to prescribing or in the course of treatment. In the case where it is not feasible to make changes to medication, adjunctive therapies should be considered. Keywords: weight gain, weight loss, weight neutral, adverse effects of medications, obesity, adjunctive therapyWharton SRaiber LSerodio KJLee JChristensen RAGDove Medical Pressarticleweight gainweight lossweight neutraladverse effects of medicationsobesityadjunctive therapySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 427-438 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	weight gain weight loss weight neutral adverse effects of medications obesity adjunctive therapy Specialties of internal medicine RC581-951
spellingShingle	weight gain weight loss weight neutral adverse effects of medications obesity adjunctive therapy Specialties of internal medicine RC581-951 Wharton S Raiber L Serodio KJ Lee J Christensen RAG Medications that cause weight gain and alternatives in Canada: a narrative review
description	Sean Wharton,1,2 Lilian Raiber,1 Kristin J Serodio,1 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Toronto, Canada; 2School of Kinesiology and Health Science, York University, Toronto, Canada Background: The cause of the obesity epidemic is multifactorial, but may, in part, be related to medication-induced weight gain. While clinicians may strive to do their best to select pharmacotherapy(ies) that has the least negative impact on weight, the literature regarding the weight effects of medication is often limited and devoid of alternative therapies. Results: Antipsychotics, antidepressants, antihyperglycemics, antihypertensives and corticosteroids all contain medications that were associated with significant weight gain. However, there are several medication alternatives within the majority of these classes associated with weight neutral or even weight loss effects. Further, while not all of the classes of medication examined in this review have weight-favorable alternatives, there exist many other tools to mitigate weight gain associated with medication use, such as changes in dosing, medication delivery or the use of adjunctive therapies. Conclusion: Medication-induced weight gain can be frustrating for both the patient and the clinician. As the use of pharmaceuticals continues to increase, it is pertinent for clinicians to consider the weight effects of medications prior to prescribing or in the course of treatment. In the case where it is not feasible to make changes to medication, adjunctive therapies should be considered. Keywords: weight gain, weight loss, weight neutral, adverse effects of medications, obesity, adjunctive therapy
format	article
author	Wharton S Raiber L Serodio KJ Lee J Christensen RAG
author_facet	Wharton S Raiber L Serodio KJ Lee J Christensen RAG
author_sort	Wharton S
title	Medications that cause weight gain and alternatives in Canada: a narrative review
title_short	Medications that cause weight gain and alternatives in Canada: a narrative review
title_full	Medications that cause weight gain and alternatives in Canada: a narrative review
title_fullStr	Medications that cause weight gain and alternatives in Canada: a narrative review
title_full_unstemmed	Medications that cause weight gain and alternatives in Canada: a narrative review
title_sort	medications that cause weight gain and alternatives in canada: a narrative review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/4cfe91e75fd34c9fb3a80152c7c6e196
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Medications that cause weight gain and alternatives in Canada: a narrative review

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