Human Recombinant DNase I (Pulmozyme<sup>®</sup>) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA

Tumor-associated cell-free DNAs (cfDNA) play an important role in the promotion of metastases. Previous studies proved the high antimetastatic potential of bovine pancreatic DNase I and identified short interspersed nuclear elements (SINEs) and long interspersed nuclear elements (LINEs)and fragments...

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Autores principales:	Ludmila Alekseeva, Aleksandra Sen’kova, Innokenty Savin, Marina Zenkova, Nadezhda Mironova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNase I Pulmozyme<sup>®</sup> drug repurposing circulating cell-free DNA neutrophil extracellular traps SINE elements Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4cff534030294ce59b65306735044e74
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Human Recombinant DNase I (Pulmozyme<sup>®</sup>) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA

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