Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders

Abstract In patients with cardiovascular disorders, blood total ketone body (TKB) levels increase with worsening heart failure and are consumed as an alternative fuel to fatty acid and glucose. We investigated factors contributing to the increase in the blood TKB levels in patients with cardiovascul...

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Autores principales:	Yusuke Kashiwagi, Tomohisa Nagoshi, Yasunori Inoue, Yoshiro Tanaka, Hirotake Takahashi, Yuhei Oi, Haruka Kimura, Kousuke Minai, Michihiro Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d01081c9a0c44968f0c0b90e9e0da01
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spelling	oai:doaj.org-article:4d01081c9a0c44968f0c0b90e9e0da012021-12-02T11:45:03ZClose linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders10.1038/s41598-021-86126-02045-2322https://doaj.org/article/4d01081c9a0c44968f0c0b90e9e0da012021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86126-0https://doaj.org/toc/2045-2322Abstract In patients with cardiovascular disorders, blood total ketone body (TKB) levels increase with worsening heart failure and are consumed as an alternative fuel to fatty acid and glucose. We investigated factors contributing to the increase in the blood TKB levels in patients with cardiovascular disorders. The study population consisted of 1030 consecutive patients who underwent cardiac catheterization. Covariance structure analyses were performed to clarify the direct contribution of hemodynamic parameters, including the left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic volume index (LVESVI), left ventricular end-diastolic volume index (LVEDVI), and B-type natriuretic peptide (BNP) levels, to TKB by excluding other confounding factors. These analyses showed that the TKB levels were significantly associated with the BNP level (P = 0.003) but not the LVEDP, LVESVI, or LVEDVI levels. This was clearly demonstrated on a two-dimensional contour line by Bayesian structure equation modeling. The TKB level was positively correlated with the BNP level, but not LVEDP, LVESVI or LVEDVI. These findings suggested that elevated blood TKB levels were more strongly stimulated by the increase in BNP than by hemodynamic deterioration. BNP might induce the elevation of TKB levels for use as an important alternative fuel in the failing heart.Yusuke KashiwagiTomohisa NagoshiYasunori InoueYoshiro TanakaHirotake TakahashiYuhei OiHaruka KimuraKousuke MinaiMichihiro YoshimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yusuke Kashiwagi Tomohisa Nagoshi Yasunori Inoue Yoshiro Tanaka Hirotake Takahashi Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
description	Abstract In patients with cardiovascular disorders, blood total ketone body (TKB) levels increase with worsening heart failure and are consumed as an alternative fuel to fatty acid and glucose. We investigated factors contributing to the increase in the blood TKB levels in patients with cardiovascular disorders. The study population consisted of 1030 consecutive patients who underwent cardiac catheterization. Covariance structure analyses were performed to clarify the direct contribution of hemodynamic parameters, including the left ventricular end-diastolic pressure (LVEDP), left ventricular end-systolic volume index (LVESVI), left ventricular end-diastolic volume index (LVEDVI), and B-type natriuretic peptide (BNP) levels, to TKB by excluding other confounding factors. These analyses showed that the TKB levels were significantly associated with the BNP level (P = 0.003) but not the LVEDP, LVESVI, or LVEDVI levels. This was clearly demonstrated on a two-dimensional contour line by Bayesian structure equation modeling. The TKB level was positively correlated with the BNP level, but not LVEDP, LVESVI or LVEDVI. These findings suggested that elevated blood TKB levels were more strongly stimulated by the increase in BNP than by hemodynamic deterioration. BNP might induce the elevation of TKB levels for use as an important alternative fuel in the failing heart.
format	article
author	Yusuke Kashiwagi Tomohisa Nagoshi Yasunori Inoue Yoshiro Tanaka Hirotake Takahashi Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura
author_facet	Yusuke Kashiwagi Tomohisa Nagoshi Yasunori Inoue Yoshiro Tanaka Hirotake Takahashi Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura
author_sort	Yusuke Kashiwagi
title	Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
title_short	Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
title_full	Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
title_fullStr	Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
title_full_unstemmed	Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
title_sort	close linkage between blood total ketone body levels and b-type natriuretic peptide levels in patients with cardiovascular disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d01081c9a0c44968f0c0b90e9e0da01
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Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders

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