MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunn...

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Autores principales:	Klemens Wild, Milan Aleksić, Karine Lapouge, Keven D. Juaire, Dirk Flemming, Stefan Pfeffer, Irmgard Sinning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d053c81525e4a33b74dd170513e50d3
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spelling	oai:doaj.org-article:4d053c81525e4a33b74dd170513e50d32021-12-02T16:49:14ZMetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments10.1038/s41467-020-14603-72041-1723https://doaj.org/article/4d053c81525e4a33b74dd170513e50d32020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14603-7https://doaj.org/toc/2041-1723The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.Klemens WildMilan AleksićKarine LapougeKeven D. JuaireDirk FlemmingStefan PfefferIrmgard SinningNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Klemens Wild Milan Aleksić Karine Lapouge Keven D. Juaire Dirk Flemming Stefan Pfeffer Irmgard Sinning MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
description	The ErbB3 receptor binding protein Ebp1 binds to ribosomes and is linked to translational control. Here, the authors present the cryo-EM structure of human Ebp1 bound to a non-translating 80S ribosome and find that Ebp1 blocks the tunnel exit and recruits the rRNA expansion segment ES27L to the tunnel exit.
format	article
author	Klemens Wild Milan Aleksić Karine Lapouge Keven D. Juaire Dirk Flemming Stefan Pfeffer Irmgard Sinning
author_facet	Klemens Wild Milan Aleksić Karine Lapouge Keven D. Juaire Dirk Flemming Stefan Pfeffer Irmgard Sinning
author_sort	Klemens Wild
title	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_short	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_full	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_fullStr	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_full_unstemmed	MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
title_sort	metap-like ebp1 occupies the human ribosomal tunnel exit and recruits flexible rrna expansion segments
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4d053c81525e4a33b74dd170513e50d3
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MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments

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