Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia
Abstract The current study aimed to explore age-variant trait differences of cortical gray matter volume (GMV) in a unique sample of first-episode and treatment-naïve patients with schizophrenia. A total of 158 subjects, including 26 adolescent-onset patients and 49 adult-onset patients as well as 8...
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Nature Portfolio
2017
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oai:doaj.org-article:4d05603ac0c0449993a1f76f20ce37b32021-12-02T15:06:03ZDifferential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia10.1038/s41598-017-10688-12045-2322https://doaj.org/article/4d05603ac0c0449993a1f76f20ce37b32017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10688-1https://doaj.org/toc/2045-2322Abstract The current study aimed to explore age-variant trait differences of cortical gray matter volume (GMV) in a unique sample of first-episode and treatment-naïve patients with schizophrenia. A total of 158 subjects, including 26 adolescent-onset patients and 49 adult-onset patients as well as 83 age- and gender-matched controls were scanned using a 3T MRI scanner. Voxel-based morphometry (VBM) following Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra (DARTEL) was used to explore group differences between patients and controls in regional GMV. We found that patients with schizophrenia had decreased GMV in the left parietal postcentral region that extended to the left frontal regions, the right middle temporal gyrus, the occipital lobe and the right cerebellum posterior pyramis. Further analysis showed a distinct pattern of gray matter alterations in adolescent-onset patients compared with both healthy controls and adult-onset patients. Relative to healthy controls, adolescent-onset patients showed GMV alterations in the left parietal postcentral gyrus, parahippocampal gyrus and right cerebellum posterior pyramis, while GMV deficits in adult-onset patients were focused on the cingulo-fronto-temporal module and right occipital regions. Our study identified differential cortical gray matter deficits between adolescent- and adulthood-onset patients with schizophrenia, which suggests that the cortical abnormalities in schizophrenia are likely adjusted by the developmental community structure of the human brain.Chengcheng ZhangQiang WangPeiyan NiWei DengYinfei LiLiansheng ZhaoXiaohong MaYingcheng WangHua YuXiaojing LiPingping ZhangYajing MengSugai LiangMingli LiTao LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Chengcheng Zhang Qiang Wang Peiyan Ni Wei Deng Yinfei Li Liansheng Zhao Xiaohong Ma Yingcheng Wang Hua Yu Xiaojing Li Pingping Zhang Yajing Meng Sugai Liang Mingli Li Tao Li Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| description |
Abstract The current study aimed to explore age-variant trait differences of cortical gray matter volume (GMV) in a unique sample of first-episode and treatment-naïve patients with schizophrenia. A total of 158 subjects, including 26 adolescent-onset patients and 49 adult-onset patients as well as 83 age- and gender-matched controls were scanned using a 3T MRI scanner. Voxel-based morphometry (VBM) following Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra (DARTEL) was used to explore group differences between patients and controls in regional GMV. We found that patients with schizophrenia had decreased GMV in the left parietal postcentral region that extended to the left frontal regions, the right middle temporal gyrus, the occipital lobe and the right cerebellum posterior pyramis. Further analysis showed a distinct pattern of gray matter alterations in adolescent-onset patients compared with both healthy controls and adult-onset patients. Relative to healthy controls, adolescent-onset patients showed GMV alterations in the left parietal postcentral gyrus, parahippocampal gyrus and right cerebellum posterior pyramis, while GMV deficits in adult-onset patients were focused on the cingulo-fronto-temporal module and right occipital regions. Our study identified differential cortical gray matter deficits between adolescent- and adulthood-onset patients with schizophrenia, which suggests that the cortical abnormalities in schizophrenia are likely adjusted by the developmental community structure of the human brain. |
| format |
article |
| author |
Chengcheng Zhang Qiang Wang Peiyan Ni Wei Deng Yinfei Li Liansheng Zhao Xiaohong Ma Yingcheng Wang Hua Yu Xiaojing Li Pingping Zhang Yajing Meng Sugai Liang Mingli Li Tao Li |
| author_facet |
Chengcheng Zhang Qiang Wang Peiyan Ni Wei Deng Yinfei Li Liansheng Zhao Xiaohong Ma Yingcheng Wang Hua Yu Xiaojing Li Pingping Zhang Yajing Meng Sugai Liang Mingli Li Tao Li |
| author_sort |
Chengcheng Zhang |
| title |
Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| title_short |
Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| title_full |
Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| title_fullStr |
Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| title_full_unstemmed |
Differential Cortical Gray Matter Deficits in Adolescent- and Adult-Onset First-Episode Treatment-Naïve Patients with Schizophrenia |
| title_sort |
differential cortical gray matter deficits in adolescent- and adult-onset first-episode treatment-naïve patients with schizophrenia |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4d05603ac0c0449993a1f76f20ce37b3 |
| work_keys_str_mv |
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