Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation

Abstract Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical challenge, highlighting the need for new therapeut...

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Autores principales:	Sandeep Kumar Parvathareddy, Abdul K. Siraj, Ismail A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Khawla S. Al-Kuraya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d0abb22ea52428a9864906c7c704522
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spelling	oai:doaj.org-article:4d0abb22ea52428a9864906c7c7045222021-12-02T12:09:51ZDifferential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation10.1038/s41598-021-83276-z2045-2322https://doaj.org/article/4d0abb22ea52428a9864906c7c7045222021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83276-zhttps://doaj.org/toc/2045-2322Abstract Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical challenge, highlighting the need for new therapeutic strategies. This study was performed to compare the expression of PD-L1 in primary epithelial ovarian cancer (EOC) and their corresponding peritoneal metastases, as well as to evaluate its correlation with clinico-pathological parameters. In total, 194 treatment naïve paired EOC and peritoneal metastasis were analyzed by immunohistochemistry for PD-L1 expression. Clinico-pathological information was available for all patients. Significant differences in PD-L1 expression were found between primary EOC and peritoneal metastasis (p < 0.0001). We found discordant tumor cell PD-L1 expression between primary tumors and corresponding peritoneal metastasis in 34% (66/194) of cases. Furthermore, PD-L1 expression in peritoneal metastasis samples was significantly associated with adverse prognostic factors, such as high proliferative index (Ki67) (p = 0.0039) and high histologic grade (p = 0.0330). In conclusion, the discordance of PD-L1 expression between primary EOC and corresponding peritoneal metastases suggests that its assessment as a potential biomarker for predicting response to anti-PD-L1 therapy may require analysis of metastatic lesions.Sandeep Kumar ParvathareddyAbdul K. SirajIsmail A. Al-BadawiAsma TulbahFouad Al-DayelKhawla S. Al-KurayaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandeep Kumar Parvathareddy Abdul K. Siraj Ismail A. Al-Badawi Asma Tulbah Fouad Al-Dayel Khawla S. Al-Kuraya Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
description	Abstract Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst prognosis and highest mortality rate. The lack of curative treatment and the high relapse rate, especially in advanced OC, continues to present a clinical challenge, highlighting the need for new therapeutic strategies. This study was performed to compare the expression of PD-L1 in primary epithelial ovarian cancer (EOC) and their corresponding peritoneal metastases, as well as to evaluate its correlation with clinico-pathological parameters. In total, 194 treatment naïve paired EOC and peritoneal metastasis were analyzed by immunohistochemistry for PD-L1 expression. Clinico-pathological information was available for all patients. Significant differences in PD-L1 expression were found between primary EOC and peritoneal metastasis (p < 0.0001). We found discordant tumor cell PD-L1 expression between primary tumors and corresponding peritoneal metastasis in 34% (66/194) of cases. Furthermore, PD-L1 expression in peritoneal metastasis samples was significantly associated with adverse prognostic factors, such as high proliferative index (Ki67) (p = 0.0039) and high histologic grade (p = 0.0330). In conclusion, the discordance of PD-L1 expression between primary EOC and corresponding peritoneal metastases suggests that its assessment as a potential biomarker for predicting response to anti-PD-L1 therapy may require analysis of metastatic lesions.
format	article
author	Sandeep Kumar Parvathareddy Abdul K. Siraj Ismail A. Al-Badawi Asma Tulbah Fouad Al-Dayel Khawla S. Al-Kuraya
author_facet	Sandeep Kumar Parvathareddy Abdul K. Siraj Ismail A. Al-Badawi Asma Tulbah Fouad Al-Dayel Khawla S. Al-Kuraya
author_sort	Sandeep Kumar Parvathareddy
title	Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
title_short	Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
title_full	Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
title_fullStr	Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
title_full_unstemmed	Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
title_sort	differential expression of pd-l1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d0abb22ea52428a9864906c7c704522
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Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation

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