A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium levels and generating reactive oxygen species....

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Autores principales:	Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4d14647112154fb9bb2c49c0fb14d6b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:4d14647112154fb9bb2c49c0fb14d6b72021-12-02T11:56:22ZA dopamine metabolite stabilizes neurotoxic amyloid-β oligomers10.1038/s42003-020-01490-32399-3642https://doaj.org/article/4d14647112154fb9bb2c49c0fb14d6b72021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01490-3https://doaj.org/toc/2399-3642Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium levels and generating reactive oxygen species. This study connects Aβ aggregation with processes regulating cellular homeostasis in the brain.Rodrigo CataldiSean ChiaKatarina PisaniFrancesco S. RuggeriCatherine K. XuTomas ŠneiderisMichele PerniSunehera SarwatPriyanka JoshiJanet R. KumitaSara LinseJohnny HabchiTuomas P. J. KnowlesBenedetta ManniniChristopher M. DobsonMichele VendruscoloNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rodrigo Cataldi Sean Chia Katarina Pisani Francesco S. Ruggeri Catherine K. Xu Tomas Šneideris Michele Perni Sunehera Sarwat Priyanka Joshi Janet R. Kumita Sara Linse Johnny Habchi Tuomas P. J. Knowles Benedetta Mannini Christopher M. Dobson Michele Vendruscolo A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
description	Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium levels and generating reactive oxygen species. This study connects Aβ aggregation with processes regulating cellular homeostasis in the brain.
format	article
author	Rodrigo Cataldi Sean Chia Katarina Pisani Francesco S. Ruggeri Catherine K. Xu Tomas Šneideris Michele Perni Sunehera Sarwat Priyanka Joshi Janet R. Kumita Sara Linse Johnny Habchi Tuomas P. J. Knowles Benedetta Mannini Christopher M. Dobson Michele Vendruscolo
author_facet	Rodrigo Cataldi Sean Chia Katarina Pisani Francesco S. Ruggeri Catherine K. Xu Tomas Šneideris Michele Perni Sunehera Sarwat Priyanka Joshi Janet R. Kumita Sara Linse Johnny Habchi Tuomas P. J. Knowles Benedetta Mannini Christopher M. Dobson Michele Vendruscolo
author_sort	Rodrigo Cataldi
title	A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
title_short	A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
title_full	A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
title_fullStr	A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
title_full_unstemmed	A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
title_sort	dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d14647112154fb9bb2c49c0fb14d6b7
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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

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