Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering

Stem cells have been extensively used in regenerative medicine and tissue engineering; however, they often lose their functionality because of the inflammatory microenvironment. This leads to their poor survival, retention, and engraftment at transplantation sites. Considering the rapid loss of tran...

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Autores principales:	Muhammad Shafiq, Onaza Ali, Seong-Beom Han, Dong-Hwee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	biomaterials stem cell mechanobiology cell fate modulation immunosuppression cell therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4d14a10ce3e84b849e42625e5d1ff2ba
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spelling	oai:doaj.org-article:4d14a10ce3e84b849e42625e5d1ff2ba2021-12-03T06:27:08ZMechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering2296-634X10.3389/fcell.2021.747398https://doaj.org/article/4d14a10ce3e84b849e42625e5d1ff2ba2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.747398/fullhttps://doaj.org/toc/2296-634XStem cells have been extensively used in regenerative medicine and tissue engineering; however, they often lose their functionality because of the inflammatory microenvironment. This leads to their poor survival, retention, and engraftment at transplantation sites. Considering the rapid loss of transplanted cells due to poor cell-cell and cell-extracellular matrix (ECM) interactions during transplantation, it has been reasoned that stem cells mainly mediate reparative responses via paracrine mechanisms, including the secretion of extracellular vesicles (EVs). Ameliorating poor cell-cell and cell-ECM interactions may obviate the limitations associated with the poor retention and engraftment of transplanted cells and enable them to mediate tissue repair through the sustained and localized presentation of secreted bioactive cues. Biomaterial-mediated strategies may be leveraged to confer stem cells enhanced immunomodulatory properties, as well as better engraftment and retention at the target site. In these approaches, biomaterials have been exploited to spatiotemporally present bioactive cues to stem cell-laden platforms (e.g., aggregates, microtissues, and tissue-engineered constructs). An array of biomaterials, such as nanoparticles, hydrogels, and scaffolds, has been exploited to facilitate stem cells function at the target site. Additionally, biomaterials can be harnessed to suppress the inflammatory microenvironment to induce enhanced tissue repair. In this review, we summarize biomaterial-based platforms that impact stem cell function for better tissue repair that may have broader implications for the treatment of various diseases as well as tissue regeneration.Muhammad ShafiqOnaza AliSeong-Beom HanDong-Hwee KimDong-Hwee KimFrontiers Media S.A.articlebiomaterialsstem cellmechanobiologycell fate modulationimmunosuppressioncell therapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomaterials stem cell mechanobiology cell fate modulation immunosuppression cell therapy Biology (General) QH301-705.5
spellingShingle	biomaterials stem cell mechanobiology cell fate modulation immunosuppression cell therapy Biology (General) QH301-705.5 Muhammad Shafiq Onaza Ali Seong-Beom Han Dong-Hwee Kim Dong-Hwee Kim Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
description	Stem cells have been extensively used in regenerative medicine and tissue engineering; however, they often lose their functionality because of the inflammatory microenvironment. This leads to their poor survival, retention, and engraftment at transplantation sites. Considering the rapid loss of transplanted cells due to poor cell-cell and cell-extracellular matrix (ECM) interactions during transplantation, it has been reasoned that stem cells mainly mediate reparative responses via paracrine mechanisms, including the secretion of extracellular vesicles (EVs). Ameliorating poor cell-cell and cell-ECM interactions may obviate the limitations associated with the poor retention and engraftment of transplanted cells and enable them to mediate tissue repair through the sustained and localized presentation of secreted bioactive cues. Biomaterial-mediated strategies may be leveraged to confer stem cells enhanced immunomodulatory properties, as well as better engraftment and retention at the target site. In these approaches, biomaterials have been exploited to spatiotemporally present bioactive cues to stem cell-laden platforms (e.g., aggregates, microtissues, and tissue-engineered constructs). An array of biomaterials, such as nanoparticles, hydrogels, and scaffolds, has been exploited to facilitate stem cells function at the target site. Additionally, biomaterials can be harnessed to suppress the inflammatory microenvironment to induce enhanced tissue repair. In this review, we summarize biomaterial-based platforms that impact stem cell function for better tissue repair that may have broader implications for the treatment of various diseases as well as tissue regeneration.
format	article
author	Muhammad Shafiq Onaza Ali Seong-Beom Han Dong-Hwee Kim Dong-Hwee Kim
author_facet	Muhammad Shafiq Onaza Ali Seong-Beom Han Dong-Hwee Kim Dong-Hwee Kim
author_sort	Muhammad Shafiq
title	Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
title_short	Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
title_full	Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
title_fullStr	Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
title_full_unstemmed	Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering
title_sort	mechanobiological strategies to enhance stem cell functionality for regenerative medicine and tissue engineering
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4d14a10ce3e84b849e42625e5d1ff2ba
work_keys_str_mv	AT muhammadshafiq mechanobiologicalstrategiestoenhancestemcellfunctionalityforregenerativemedicineandtissueengineering AT onazaali mechanobiologicalstrategiestoenhancestemcellfunctionalityforregenerativemedicineandtissueengineering AT seongbeomhan mechanobiologicalstrategiestoenhancestemcellfunctionalityforregenerativemedicineandtissueengineering AT donghweekim mechanobiologicalstrategiestoenhancestemcellfunctionalityforregenerativemedicineandtissueengineering AT donghweekim mechanobiologicalstrategiestoenhancestemcellfunctionalityforregenerativemedicineandtissueengineering
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Mechanobiological Strategies to Enhance Stem Cell Functionality for Regenerative Medicine and Tissue Engineering

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