Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections

Abstract Treatment of prosthetic joint infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibiotic therapy, due to the formation of biofilm. We introduce a non-invasive method for thermal destruction of biofilm on metallic implants using high-frequency (>10...

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Autores principales:	Rajiv Chopra, Sumbul Shaikh, Yonatan Chatzinoff, Imalka Munaweera, Bingbing Cheng, Seth M. Daly, Yin Xi, Chenchen Bing, Dennis Burns, David E. Greenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d1662219df9473da4ee9ac0d2b85f08
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spelling	oai:doaj.org-article:4d1662219df9473da4ee9ac0d2b85f082021-12-02T15:06:26ZEmploying high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections10.1038/s41598-017-07321-62045-2322https://doaj.org/article/4d1662219df9473da4ee9ac0d2b85f082017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07321-6https://doaj.org/toc/2045-2322Abstract Treatment of prosthetic joint infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibiotic therapy, due to the formation of biofilm. We introduce a non-invasive method for thermal destruction of biofilm on metallic implants using high-frequency (>100 kHz) alternating magnetic fields (AMF). In vitro investigations demonstrate a >5-log reduction in bacterial counts after 5 minutes of AMF exposure. Confocal and scanning electron microscopy confirm removal of biofilm matrix components within 1 minute of AMF exposure, and combination studies of antibiotics and AMF demonstrate a 5-log increase in the sensitivity of Pseudomonas aeruginosa to ciprofloxacin. Finite element analysis (FEA) simulations demonstrate that intermittent AMF exposures can achieve uniform surface heating of a prosthetic knee joint. In vivo studies confirm thermal damage is confined to a localized region (<2 mm) around the implant, and safety can be achieved using acoustic monitoring for the presence of surface boiling. These initial studies support the hypothesis that AMF exposures can eradicate biofilm on metal implants, and may enhance the effectiveness of conventional antibiotics.Rajiv ChopraSumbul ShaikhYonatan ChatzinoffImalka MunaweeraBingbing ChengSeth M. DalyYin XiChenchen BingDennis BurnsDavid E. GreenbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajiv Chopra Sumbul Shaikh Yonatan Chatzinoff Imalka Munaweera Bingbing Cheng Seth M. Daly Yin Xi Chenchen Bing Dennis Burns David E. Greenberg Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
description	Abstract Treatment of prosthetic joint infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibiotic therapy, due to the formation of biofilm. We introduce a non-invasive method for thermal destruction of biofilm on metallic implants using high-frequency (>100 kHz) alternating magnetic fields (AMF). In vitro investigations demonstrate a >5-log reduction in bacterial counts after 5 minutes of AMF exposure. Confocal and scanning electron microscopy confirm removal of biofilm matrix components within 1 minute of AMF exposure, and combination studies of antibiotics and AMF demonstrate a 5-log increase in the sensitivity of Pseudomonas aeruginosa to ciprofloxacin. Finite element analysis (FEA) simulations demonstrate that intermittent AMF exposures can achieve uniform surface heating of a prosthetic knee joint. In vivo studies confirm thermal damage is confined to a localized region (<2 mm) around the implant, and safety can be achieved using acoustic monitoring for the presence of surface boiling. These initial studies support the hypothesis that AMF exposures can eradicate biofilm on metal implants, and may enhance the effectiveness of conventional antibiotics.
format	article
author	Rajiv Chopra Sumbul Shaikh Yonatan Chatzinoff Imalka Munaweera Bingbing Cheng Seth M. Daly Yin Xi Chenchen Bing Dennis Burns David E. Greenberg
author_facet	Rajiv Chopra Sumbul Shaikh Yonatan Chatzinoff Imalka Munaweera Bingbing Cheng Seth M. Daly Yin Xi Chenchen Bing Dennis Burns David E. Greenberg
author_sort	Rajiv Chopra
title	Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
title_short	Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
title_full	Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
title_fullStr	Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
title_full_unstemmed	Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
title_sort	employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d1662219df9473da4ee9ac0d2b85f08
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Employing high-frequency alternating magnetic fields for the non-invasive treatment of prosthetic joint infections

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