Immunological fingerprint of 4CMenB recombinant antigens via protein microarray reveals key immunosignatures correlating with bactericidal activity

Immunological fingerprint of 4CMenB recombinant antigens via protein microarray reveals key immunosignatures correlating with bactericidal activity

4CMenB is an approved multi-component vaccine against Serogroup B meningococcus. Here the authors develop a protein microarray for three major 4CMenB antigenic components (fHbp, NHBA and NadA) and describe antibody repertoires in sera from vaccinated infants, adolescents and adults correlating with...

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Main Authors: E. Bartolini, E. Borgogni, M. Bruttini, A. Muzzi, M. Giuliani, S. Iozzi, R. Petracca, M. Martinelli, S. Bonacci, S. Marchi, C. Brettoni, C. Donati, G. Torricelli, S. Guidotti, M. Domina, C. Beninati, G. Teti, F. Felici, R. Rappuoli, F. Castellino, G. Del Giudice, V. Masignani, M. Pizza, D. Maione
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/4d17db449f7f4c719c7020da2ad12e49
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https://doaj.org/article/4d17db449f7f4c719c7020da2ad12e49

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