Oxygen: A Stimulus, Not “Only” a Drug

Depending on the oxygen partial pressure in a tissue, the therapeutic effect of oxygenation can vary from simple substance substitution up to hyperbaric oxygenation when breathing hyperbaric oxygen at 2.5–3.0 ATA. Surprisingly, new data showed that it is not only the oxygen supply that matters as ev...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Costantino Balestra, Jacek Kot
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxygen hyperbaric oxygen epigenetics normobaric oxygen paradox hyperoxic-hypoxic paradox Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4d18bfbca2a74684ae50dcf398ed21d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4d18bfbca2a74684ae50dcf398ed21d0
record_format	dspace
spelling	oai:doaj.org-article:4d18bfbca2a74684ae50dcf398ed21d02021-11-25T18:18:12ZOxygen: A Stimulus, Not “Only” a Drug10.3390/medicina571111611648-91441010-660Xhttps://doaj.org/article/4d18bfbca2a74684ae50dcf398ed21d02021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1161https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Depending on the oxygen partial pressure in a tissue, the therapeutic effect of oxygenation can vary from simple substance substitution up to hyperbaric oxygenation when breathing hyperbaric oxygen at 2.5–3.0 ATA. Surprisingly, new data showed that it is not only the oxygen supply that matters as even a minimal increase in the partial pressure of oxygen is efficient in triggering cellular reactions by eliciting the production of hypoxia-inducible factors and heat-shock proteins. Moreover, it was shown that extreme environments could also interact with the genome; in fact, epigenetics appears to play a major role in extreme environments and exercise, especially when changes in oxygen partial pressure are involved. Hyperbaric oxygen therapy is, essentially, “intermittent oxygen” exposure. We must investigate hyperbaric oxygen with a new paradigm of treating oxygen as a potent stimulus of the molecular network of reactions.Costantino BalestraJacek KotMDPI AGarticleoxygenhyperbaric oxygenepigeneticsnormobaric oxygen paradoxhyperoxic-hypoxic paradoxMedicine (General)R5-920ENMedicina, Vol 57, Iss 1161, p 1161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxygen hyperbaric oxygen epigenetics normobaric oxygen paradox hyperoxic-hypoxic paradox Medicine (General) R5-920
spellingShingle	oxygen hyperbaric oxygen epigenetics normobaric oxygen paradox hyperoxic-hypoxic paradox Medicine (General) R5-920 Costantino Balestra Jacek Kot Oxygen: A Stimulus, Not “Only” a Drug
description	Depending on the oxygen partial pressure in a tissue, the therapeutic effect of oxygenation can vary from simple substance substitution up to hyperbaric oxygenation when breathing hyperbaric oxygen at 2.5–3.0 ATA. Surprisingly, new data showed that it is not only the oxygen supply that matters as even a minimal increase in the partial pressure of oxygen is efficient in triggering cellular reactions by eliciting the production of hypoxia-inducible factors and heat-shock proteins. Moreover, it was shown that extreme environments could also interact with the genome; in fact, epigenetics appears to play a major role in extreme environments and exercise, especially when changes in oxygen partial pressure are involved. Hyperbaric oxygen therapy is, essentially, “intermittent oxygen” exposure. We must investigate hyperbaric oxygen with a new paradigm of treating oxygen as a potent stimulus of the molecular network of reactions.
format	article
author	Costantino Balestra Jacek Kot
author_facet	Costantino Balestra Jacek Kot
author_sort	Costantino Balestra
title	Oxygen: A Stimulus, Not “Only” a Drug
title_short	Oxygen: A Stimulus, Not “Only” a Drug
title_full	Oxygen: A Stimulus, Not “Only” a Drug
title_fullStr	Oxygen: A Stimulus, Not “Only” a Drug
title_full_unstemmed	Oxygen: A Stimulus, Not “Only” a Drug
title_sort	oxygen: a stimulus, not “only” a drug
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d18bfbca2a74684ae50dcf398ed21d0
work_keys_str_mv	AT costantinobalestra oxygenastimulusnotonlyadrug AT jacekkot oxygenastimulusnotonlyadrug
_version_	1718411378073534464

Oxygen: A Stimulus, Not “Only” a Drug

Ejemplares similares