Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study

Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study

Abstract There is a lack of tangible measures for directed public health action to halt the increase in weight and cancer. We estimated the fraction and preventable cases of all and major body fatness-related cancers attributable to 7-years weight gain (≥ 2 kg). We assessed validated self-reported a...

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Autores principales: Marisa da Silva, Maarit A. Laaksonen, Lauren Lissner, Elisabete Weiderpass, Charlotta Rylander
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4d21cf97f3ad46d0adc026da1b39f18b
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spelling oai:doaj.org-article:4d21cf97f3ad46d0adc026da1b39f18b2021-12-02T10:54:15ZPreventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study10.1038/s41598-021-83027-02045-2322https://doaj.org/article/4d21cf97f3ad46d0adc026da1b39f18b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83027-0https://doaj.org/toc/2045-2322Abstract There is a lack of tangible measures for directed public health action to halt the increase in weight and cancer. We estimated the fraction and preventable cases of all and major body fatness-related cancers attributable to 7-years weight gain (≥ 2 kg). We assessed validated self-reported anthropometrics from 44,114 women aged 34–49 years at the enrolment in 1991–1992 and from a second questionnaire in 1998, with follow-up through December 31, 2015. Over 18 years, 3216 body fatness-related cancers and 2041 deaths were reported. Nearly 70% of women experienced weight gain and the average weight change was 4 kg. We observed a substantial proportional impact of weight gain on pancreatic cancer with a population attributable fraction (PAF) of 41.8% (95% CI 8.1–63.1) and a high absolute impact on postmenopausal breast cancer with 4403 preventable cases (95% CI 1064–7299) and a PAF of 16.8% (95% CI 4.1–27.8), and colorectal cancer with 3857 preventable cases (95% CI 1313–5990) and a PAF of 22.6% (95% CI 7.7–35.1). Avoiding weight gain over seven years in middle adulthood could have prevented a considerable proportion of the cancer burden and thousands of cancer cases in women in Norway.Marisa da SilvaMaarit A. LaaksonenLauren LissnerElisabete WeiderpassCharlotta RylanderNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Marisa da Silva
Maarit A. Laaksonen
Lauren Lissner
Elisabete Weiderpass
Charlotta Rylander
Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
description Abstract There is a lack of tangible measures for directed public health action to halt the increase in weight and cancer. We estimated the fraction and preventable cases of all and major body fatness-related cancers attributable to 7-years weight gain (≥ 2 kg). We assessed validated self-reported anthropometrics from 44,114 women aged 34–49 years at the enrolment in 1991–1992 and from a second questionnaire in 1998, with follow-up through December 31, 2015. Over 18 years, 3216 body fatness-related cancers and 2041 deaths were reported. Nearly 70% of women experienced weight gain and the average weight change was 4 kg. We observed a substantial proportional impact of weight gain on pancreatic cancer with a population attributable fraction (PAF) of 41.8% (95% CI 8.1–63.1) and a high absolute impact on postmenopausal breast cancer with 4403 preventable cases (95% CI 1064–7299) and a PAF of 16.8% (95% CI 4.1–27.8), and colorectal cancer with 3857 preventable cases (95% CI 1313–5990) and a PAF of 22.6% (95% CI 7.7–35.1). Avoiding weight gain over seven years in middle adulthood could have prevented a considerable proportion of the cancer burden and thousands of cancer cases in women in Norway.
format article
author Marisa da Silva
Maarit A. Laaksonen
Lauren Lissner
Elisabete Weiderpass
Charlotta Rylander
author_facet Marisa da Silva
Maarit A. Laaksonen
Lauren Lissner
Elisabete Weiderpass
Charlotta Rylander
author_sort Marisa da Silva
title Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
title_short Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
title_full Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
title_fullStr Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
title_full_unstemmed Preventable fractions of cancer incidence attributable to 7-years weight gain in the Norwegian Women and Cancer (NOWAC) study
title_sort preventable fractions of cancer incidence attributable to 7-years weight gain in the norwegian women and cancer (nowac) study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4d21cf97f3ad46d0adc026da1b39f18b
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AT maaritalaaksonen preventablefractionsofcancerincidenceattributableto7yearsweightgaininthenorwegianwomenandcancernowacstudy
AT laurenlissner preventablefractionsofcancerincidenceattributableto7yearsweightgaininthenorwegianwomenandcancernowacstudy
AT elisabeteweiderpass preventablefractionsofcancerincidenceattributableto7yearsweightgaininthenorwegianwomenandcancernowacstudy
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