Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus
The aim of the study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis (IM) caused by EBV. Materials and methods. We examined 110 patients with a mean age of 23.3±4.2 years with IM, among whom women accounted for...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Scientific Route OÜ
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/4d22c35f913046c4a37b8243565f014a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:4d22c35f913046c4a37b8243565f014a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:4d22c35f913046c4a37b8243565f014a2021-12-03T07:43:49ZClinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus2504-56602504-567910.21303/2504-5679.2021.002177https://doaj.org/article/4d22c35f913046c4a37b8243565f014a2021-11-01T00:00:00Zhttp://journal.eu-jr.eu/health/article/view/2177https://doaj.org/toc/2504-5660https://doaj.org/toc/2504-5679The aim of the study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis (IM) caused by EBV. Materials and methods. We examined 110 patients with a mean age of 23.3±4.2 years with IM, among whom women accounted for 52.7 % (n=58). The material for the study was the serum of patients obtained during the disease course. The set of tests of patients with IM included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. Statistical processing of the obtained data was performed with “Statsoft Statistica v. 10.0 for Windows” using the methods of variation and correlation statistics. Results. The obtained results analysis revealed changes in the system of cellular and humoral parts of the immune system and the diversity of the immune response in patients with IM. The progressive nature of changes in immune parameters indicated the formation of secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. Significant changes in the cellular immune system were observed in the acute period and were characterized by the increase in the number of cells with killer activity, namely mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (IL-2 receptor), and by the Th1/Th2 ratio increase. The appointment of combination therapy including ribonucleic acid was accompanied by immunomodulatory and antiviral effects, that was reflected in a more pronounced positive dynamics of immunological parameters, namely in strengthening the proliferative response, compared with the group of patients receiving only basic therapy. Conclusion. The expediency of the combination therapy application: the drug Nuclex (ribonucleic acid) (250 mg) 2 capsules 3 times a day for 14 days and valacyclovir (500 mg) at a dose of 1000 mg (2 tablets) 3 times a day for 14 days, is justified for the correction of immune disorders in patients with IM caused by EBV.Pavlikova KseniaTetiana LiadovaOlga VolobuevaOlesya GololobovaNataliia VinnikovaScientific Route OÜarticleinfectious mononucleosisepstein-barr virusimmune responseantiviral and immunomodulatory therapyMedicineRENEUREKA: Health Sciences, Iss 6, Pp 3-9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
infectious mononucleosis epstein-barr virus immune response antiviral and immunomodulatory therapy Medicine R |
| spellingShingle |
infectious mononucleosis epstein-barr virus immune response antiviral and immunomodulatory therapy Medicine R Pavlikova Ksenia Tetiana Liadova Olga Volobueva Olesya Gololobova Nataliia Vinnikova Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| description |
The aim of the study was to evaluate the effectiveness of ribonucleic acid in the correction of immune disorders in patients with infectious mononucleosis (IM) caused by EBV.
Materials and methods. We examined 110 patients with a mean age of 23.3±4.2 years with IM, among whom women accounted for 52.7 % (n=58). The material for the study was the serum of patients obtained during the disease course. The set of tests of patients with IM included clinical and biochemical methods, enzyme-linked immunosorbent assay, polymerase chain reaction method, immunogram. Statistical processing of the obtained data was performed with “Statsoft Statistica v. 10.0 for Windows” using the methods of variation and correlation statistics.
Results. The obtained results analysis revealed changes in the system of cellular and humoral parts of the immune system and the diversity of the immune response in patients with IM. The progressive nature of changes in immune parameters indicated the formation of secondary cellular immune imbalance, activation of the humoral link, a change in the balance of immunoregulatory mediators towards Th2 cells. Significant changes in the cellular immune system were observed in the acute period and were characterized by the increase in the number of cells with killer activity, namely mature T-lymphocytes (CD3+), cytotoxic T-suppressor cells (CD8+), cells expressing the activation marker CD25+ (IL-2 receptor), and by the Th1/Th2 ratio increase. The appointment of combination therapy including ribonucleic acid was accompanied by immunomodulatory and antiviral effects, that was reflected in a more pronounced positive dynamics of immunological parameters, namely in strengthening the proliferative response, compared with the group of patients receiving only basic therapy.
Conclusion. The expediency of the combination therapy application: the drug Nuclex (ribonucleic acid) (250 mg) 2 capsules 3 times a day for 14 days and valacyclovir (500 mg) at a dose of 1000 mg (2 tablets) 3 times a day for 14 days, is justified for the correction of immune disorders in patients with IM caused by EBV. |
| format |
article |
| author |
Pavlikova Ksenia Tetiana Liadova Olga Volobueva Olesya Gololobova Nataliia Vinnikova |
| author_facet |
Pavlikova Ksenia Tetiana Liadova Olga Volobueva Olesya Gololobova Nataliia Vinnikova |
| author_sort |
Pavlikova Ksenia |
| title |
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| title_short |
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| title_full |
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| title_fullStr |
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| title_full_unstemmed |
Clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by Epstein-Barr virus |
| title_sort |
clinical and immunological efficiency of different therapy regimens in patients with infectious mononucleosis caused by epstein-barr virus |
| publisher |
Scientific Route OÜ |
| publishDate |
2021 |
| url |
https://doaj.org/article/4d22c35f913046c4a37b8243565f014a |
| work_keys_str_mv |
AT pavlikovaksenia clinicalandimmunologicalefficiencyofdifferenttherapyregimensinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT tetianaliadova clinicalandimmunologicalefficiencyofdifferenttherapyregimensinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT olgavolobueva clinicalandimmunologicalefficiencyofdifferenttherapyregimensinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT olesyagololobova clinicalandimmunologicalefficiencyofdifferenttherapyregimensinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT nataliiavinnikova clinicalandimmunologicalefficiencyofdifferenttherapyregimensinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus |
| _version_ |
1718373387582046208 |