LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer

The long-non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is a known cause of tumorigenesis. Nevertheless, it’s yet unclear how lncRNA SNHG1 influences breast cancer. Herein, we explored the mechanisms through which SNHG1 modulates breast cancer tumor progression. Our findings demonst...

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Autores principales: Mingkun Zhang, Liu Yang, Lan Hou, Xueyuan Tang
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2021
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spelling oai:doaj.org-article:4d24f2437c7b46a18a424d85228ecded2021-11-26T11:19:49ZLncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer2165-59792165-598710.1080/21655979.2021.1996305https://doaj.org/article/4d24f2437c7b46a18a424d85228ecded2021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996305https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987The long-non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is a known cause of tumorigenesis. Nevertheless, it’s yet unclear how lncRNA SNHG1 influences breast cancer. Herein, we explored the mechanisms through which SNHG1 modulates breast cancer tumor progression. Our findings demonstrated that SNHG1 is significantly upregulated in breast cancer tissues and cells. High SNHG1 levels were closely linked to reduced survival rates in breast cancer patients. SNHG1 silencing has been shown to inhibit the proliferative, migratory, and invasive activity of breast cancer cells. Moreover, SNHG1 silencing enhanced cisplatin (DDP) sensitivity of these cells through improving DDP-induced cell apoptosis. Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells. Overexpression of miR-381 inhibited tumor progression and sensitized cells to the chemotherapeutic reagent DDP. More importantly, rescue experiments demonstrated that miR-381 inhibition could inverse the tumor-suppressive effect of SNHG1 silencing in breast cancer. In summary, SNHG1 silencing suppressed tumor progression and overcame breast cancer cell DDP resistance via the epigenetic suppression of miR-381 expression. Our study revealed that SNHG1 served as a novel therapeutic target for breast cancer chemoresistance.Mingkun ZhangLiu YangLan HouXueyuan TangTaylor & Francis Grouparticlebreast cancerlong non-coding rnasmall nucleolar rna host gene 1enhancer of zeste homolog 2mir-381BiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 9239-9250 (2021)
institution DOAJ
collection DOAJ
language EN
topic breast cancer
long non-coding rna
small nucleolar rna host gene 1
enhancer of zeste homolog 2
mir-381
Biotechnology
TP248.13-248.65
spellingShingle breast cancer
long non-coding rna
small nucleolar rna host gene 1
enhancer of zeste homolog 2
mir-381
Biotechnology
TP248.13-248.65
Mingkun Zhang
Liu Yang
Lan Hou
Xueyuan Tang
LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
description The long-non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is a known cause of tumorigenesis. Nevertheless, it’s yet unclear how lncRNA SNHG1 influences breast cancer. Herein, we explored the mechanisms through which SNHG1 modulates breast cancer tumor progression. Our findings demonstrated that SNHG1 is significantly upregulated in breast cancer tissues and cells. High SNHG1 levels were closely linked to reduced survival rates in breast cancer patients. SNHG1 silencing has been shown to inhibit the proliferative, migratory, and invasive activity of breast cancer cells. Moreover, SNHG1 silencing enhanced cisplatin (DDP) sensitivity of these cells through improving DDP-induced cell apoptosis. Mechanistically, SNHG1 was found to interact with enhancer of zeste homolog 2 (EZH2), recruiting EZH2 to trigger trimethylation of histone H3 lysine 27 (H3K27me3), thus epigenetically inhibiting miR-381 transcription in these cells. Overexpression of miR-381 inhibited tumor progression and sensitized cells to the chemotherapeutic reagent DDP. More importantly, rescue experiments demonstrated that miR-381 inhibition could inverse the tumor-suppressive effect of SNHG1 silencing in breast cancer. In summary, SNHG1 silencing suppressed tumor progression and overcame breast cancer cell DDP resistance via the epigenetic suppression of miR-381 expression. Our study revealed that SNHG1 served as a novel therapeutic target for breast cancer chemoresistance.
format article
author Mingkun Zhang
Liu Yang
Lan Hou
Xueyuan Tang
author_facet Mingkun Zhang
Liu Yang
Lan Hou
Xueyuan Tang
author_sort Mingkun Zhang
title LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
title_short LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
title_full LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
title_fullStr LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
title_full_unstemmed LncRNA SNHG1 promotes tumor progression and cisplatin resistance through epigenetically silencing miR-381 in breast cancer
title_sort lncrna snhg1 promotes tumor progression and cisplatin resistance through epigenetically silencing mir-381 in breast cancer
publisher Taylor & Francis Group
publishDate 2021
url https://doaj.org/article/4d24f2437c7b46a18a424d85228ecded
work_keys_str_mv AT mingkunzhang lncrnasnhg1promotestumorprogressionandcisplatinresistancethroughepigeneticallysilencingmir381inbreastcancer
AT liuyang lncrnasnhg1promotestumorprogressionandcisplatinresistancethroughepigeneticallysilencingmir381inbreastcancer
AT lanhou lncrnasnhg1promotestumorprogressionandcisplatinresistancethroughepigeneticallysilencingmir381inbreastcancer
AT xueyuantang lncrnasnhg1promotestumorprogressionandcisplatinresistancethroughepigeneticallysilencingmir381inbreastcancer
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