Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

Abstract The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting its potential use for treating epilept...

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Autores principales:	Juan Liu, Beimeng Yang, Pei Zhou, Yingying Kong, Weiwei Hu, Geng Zhu, Weihai Ying, Weidong Li, Yun Wang, Shengtian Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d24ff607a6640cd9c2af58177b33a23
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spelling	oai:doaj.org-article:4d24ff607a6640cd9c2af58177b33a232021-12-02T12:32:03ZNicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage10.1038/s41598-017-07343-02045-2322https://doaj.org/article/4d24ff607a6640cd9c2af58177b33a232017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07343-0https://doaj.org/toc/2045-2322Abstract The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting its potential use for treating epileptogenesis. Here we evaluated the effects of NAD+ on epileptogenesis and the mechanisms underlying these effects. In pilocarpine-induced status epilepticus (SE) model mice, NAD+ was injected three times within 24.5 h after SE. NAD+ intervention significantly reduced the incidence of spontaneous recurrent seizure (SRS) and abnormal electroencephalogram (EEG) activity, rescued contextual fear memory formation, reduced neuronal loss in the CA1 region of the hippocampus at SRS stage. Furthermore, exogenous supply of NAD+ distinctly reversed the seizure-induced depletion of endogenous NAD+, reduced neuronal apoptosis in the CA1 region of the hippocampus, and reversed the augmented Acp53/p53 ratio at the early stage of epileptogenesis. Our findings demonstrated that early-stage intervention with NAD+ prevents epileptogenesis in pilocarpine-induced SE mice by suppressing neuronal apoptosis.Juan LiuBeimeng YangPei ZhouYingying KongWeiwei HuGeng ZhuWeihai YingWeidong LiYun WangShengtian LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan Liu Beimeng Yang Pei Zhou Yingying Kong Weiwei Hu Geng Zhu Weihai Ying Weidong Li Yun Wang Shengtian Li Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
description	Abstract The pathophysiologic mechanisms of epileptogenesis are poorly understood, and no effective therapy exists for suppressing epileptogenesis. Numerous reports have shown that nicotinamide adenine dinucleotide (NAD+) has neuroprotective effects, suggesting its potential use for treating epileptogenesis. Here we evaluated the effects of NAD+ on epileptogenesis and the mechanisms underlying these effects. In pilocarpine-induced status epilepticus (SE) model mice, NAD+ was injected three times within 24.5 h after SE. NAD+ intervention significantly reduced the incidence of spontaneous recurrent seizure (SRS) and abnormal electroencephalogram (EEG) activity, rescued contextual fear memory formation, reduced neuronal loss in the CA1 region of the hippocampus at SRS stage. Furthermore, exogenous supply of NAD+ distinctly reversed the seizure-induced depletion of endogenous NAD+, reduced neuronal apoptosis in the CA1 region of the hippocampus, and reversed the augmented Acp53/p53 ratio at the early stage of epileptogenesis. Our findings demonstrated that early-stage intervention with NAD+ prevents epileptogenesis in pilocarpine-induced SE mice by suppressing neuronal apoptosis.
format	article
author	Juan Liu Beimeng Yang Pei Zhou Yingying Kong Weiwei Hu Geng Zhu Weihai Ying Weidong Li Yun Wang Shengtian Li
author_facet	Juan Liu Beimeng Yang Pei Zhou Yingying Kong Weiwei Hu Geng Zhu Weihai Ying Weidong Li Yun Wang Shengtian Li
author_sort	Juan Liu
title	Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
title_short	Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
title_full	Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
title_fullStr	Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
title_full_unstemmed	Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
title_sort	nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d24ff607a6640cd9c2af58177b33a23
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_version_	1718394153373532160

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

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