Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the dege...

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Autores principales:	Natalia L. Kononenko, Gala A. Claßen, Marijn Kuijpers, Dmytro Puchkov, Tanja Maritzen, Aleksandra Tempes, Anna R. Malik, Agnieszka Skalecka, Sujoy Bera, Jacek Jaworski, Volker Haucke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d27649c1b8945efb76664268ba42b42
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spelling	oai:doaj.org-article:4d27649c1b8945efb76664268ba42b422021-12-02T14:42:35ZRetrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration10.1038/ncomms148192041-1723https://doaj.org/article/4d27649c1b8945efb76664268ba42b422017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14819https://doaj.org/toc/2041-1723The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the degeneration of cortical and thalamic neurons.Natalia L. KononenkoGala A. ClaßenMarijn KuijpersDmytro PuchkovTanja MaritzenAleksandra TempesAnna R. MalikAgnieszka SkaleckaSujoy BeraJacek JaworskiVolker HauckeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
description	The endocytic adaptor protein complex AP-2 is mostly known for its role in endocytosis and in synaptic vesicle reformation. Here the authors show that AP-2 also mediates retrograde transport of TrkB-containing autophagosomes in neurons; this process promotes neuronal complexity and prevents the degeneration of cortical and thalamic neurons.
format	article
author	Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke
author_facet	Natalia L. Kononenko Gala A. Claßen Marijn Kuijpers Dmytro Puchkov Tanja Maritzen Aleksandra Tempes Anna R. Malik Agnieszka Skalecka Sujoy Bera Jacek Jaworski Volker Haucke
author_sort	Natalia L. Kononenko
title	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_short	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_full	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_fullStr	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_full_unstemmed	Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
title_sort	retrograde transport of trkb-containing autophagosomes via the adaptor ap-2 mediates neuronal complexity and prevents neurodegeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d27649c1b8945efb76664268ba42b42
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Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

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