Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium

Abstract l-Cysteine coated zinc oxide (ZnO) nano hollow spheres were prepared as a potent drug delivery agent to eradicate Salmonella enterica serovar Typhimurium (S. typhimurium). The ZnO nano hollow spheres were synthesized by following the environmentally-friendly trisodium citrate assisted metho...

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Autores principales:	M. S. Bacchu, M. R. Ali, M. A. A. Setu, S. Akter, M. Z. H. Khan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d2c172a2a73407f9f9b06a38038200b
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spelling	oai:doaj.org-article:4d2c172a2a73407f9f9b06a38038200b2021-12-02T16:31:02ZCeftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium10.1038/s41598-021-95195-02045-2322https://doaj.org/article/4d2c172a2a73407f9f9b06a38038200b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95195-0https://doaj.org/toc/2045-2322Abstract l-Cysteine coated zinc oxide (ZnO) nano hollow spheres were prepared as a potent drug delivery agent to eradicate Salmonella enterica serovar Typhimurium (S. typhimurium). The ZnO nano hollow spheres were synthesized by following the environmentally-friendly trisodium citrate assisted method and l-cysteine (L-Cys) conjugate with its surface. ZnO/L-Cys@CFX nanocarrier drug has been fabricated by incorporating ceftizoxime with L-Cys coated ZnO nano hollow spheres and characterized using different techniques such as scanning electron microscope (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), and X-ray diffraction (XRD) etc. Furthermore, the drug-loading and encapsulation efficiency at different pH levels was measured using UV–vis spectrometer and optimized. A control and gradual manner of pH-sensitive release profile was found after investigating the release profile of CFX from the carrier drug. The antibacterial activity of ZnO/L-Cys@CFX and CFX were evaluated through the agar disc diffusion method and the broth dilution method, which indicate the antibacterial properties of antibiotics enhance after conjugating. Surprisingly, the ZnO/L-Cys@CFX exhibits a minimum inhibitory concentration (MIC) of 5 µg/ml against S. typhimurium is lower than CFX (20 µg/ml) itself. These results indicate the nanocarrier can reduce the amount of CFX dosed to eradicate S. typhimurium.M. S. BacchuM. R. AliM. A. A. SetuS. AkterM. Z. H. KhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. S. Bacchu M. R. Ali M. A. A. Setu S. Akter M. Z. H. Khan Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
description	Abstract l-Cysteine coated zinc oxide (ZnO) nano hollow spheres were prepared as a potent drug delivery agent to eradicate Salmonella enterica serovar Typhimurium (S. typhimurium). The ZnO nano hollow spheres were synthesized by following the environmentally-friendly trisodium citrate assisted method and l-cysteine (L-Cys) conjugate with its surface. ZnO/L-Cys@CFX nanocarrier drug has been fabricated by incorporating ceftizoxime with L-Cys coated ZnO nano hollow spheres and characterized using different techniques such as scanning electron microscope (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), and X-ray diffraction (XRD) etc. Furthermore, the drug-loading and encapsulation efficiency at different pH levels was measured using UV–vis spectrometer and optimized. A control and gradual manner of pH-sensitive release profile was found after investigating the release profile of CFX from the carrier drug. The antibacterial activity of ZnO/L-Cys@CFX and CFX were evaluated through the agar disc diffusion method and the broth dilution method, which indicate the antibacterial properties of antibiotics enhance after conjugating. Surprisingly, the ZnO/L-Cys@CFX exhibits a minimum inhibitory concentration (MIC) of 5 µg/ml against S. typhimurium is lower than CFX (20 µg/ml) itself. These results indicate the nanocarrier can reduce the amount of CFX dosed to eradicate S. typhimurium.
format	article
author	M. S. Bacchu M. R. Ali M. A. A. Setu S. Akter M. Z. H. Khan
author_facet	M. S. Bacchu M. R. Ali M. A. A. Setu S. Akter M. Z. H. Khan
author_sort	M. S. Bacchu
title	Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
title_short	Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
title_full	Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
title_fullStr	Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
title_full_unstemmed	Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium
title_sort	ceftizoxime loaded zno/l-cysteine based an advanced nanocarrier drug for growth inhibition of salmonella typhimurium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d2c172a2a73407f9f9b06a38038200b
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Ceftizoxime loaded ZnO/l-cysteine based an advanced nanocarrier drug for growth inhibition of Salmonella typhimurium

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