IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS

Objective: To identify whether the timing of initiation of continuous renal replacement therapy affects outcome in septic patients with acute kidney injury in term of 28 days mortality. Study Design: Cross sectional analytical study. Place and Duration of Study: This research was conducted at depart...

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Autores principales:	Muhammad Nasir, Madiha Hashmi, Muhammad Sohaib, Zahoor Ahmed, Muhammad Salman, Syed Amir Raza
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	acute kidney injury intensive care renal replacement therapy sepsis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.3450 https://doaj.org/article/4d2c3de7de1c4075880618ff97cd7b37
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spelling	oai:doaj.org-article:4d2c3de7de1c4075880618ff97cd7b372021-12-02T17:18:43ZIMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTShttps://doi.org/10.51253/pafmj.v71iSuppl-1.34500030-96482411-8842https://doaj.org/article/4d2c3de7de1c4075880618ff97cd7b372021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3450https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To identify whether the timing of initiation of continuous renal replacement therapy affects outcome in septic patients with acute kidney injury in term of 28 days mortality. Study Design: Cross sectional analytical study. Place and Duration of Study: This research was conducted at department of Anaesthesiology and critical care unit of the Aga Khan University Hospital, Karachi, from Oct 2018 to Jun 2019. Methodology: The study reviewed all adult patients aged >18 years who developed acute kidney injury after septic shock and required continuous renal replacement therapy in surgical intensive care unit. Considering the value of blood urea nitrogen, patients were classified into two groups. One was in early group that‟s was defined as blood urea nitrogen value of <100 mg/dl just before continuous renal replacement therapy initiation while the patients who have blood urea nitrogen value of ≥100 mg/dl just prior to continuous renal replacement therapy initiation were classified as late group. Kaplan-Meier survival analysis was performed and median survival was computed. Results: Forty patients were included for analysis. There were thirty patients (75%) in early group in whom continuous renal replacement therapy was started with mean blood urea nitrogen of 66 ± 20.2 mg/dL and 10 (25%) patients were in late group with mean blood urea nitrogen of 137 ± 28.4 mg/dL. The overall survival rates in both groups were 49.6%, and 10.4% at 10 and 25 days, respectively. Median survival time was not statistically significant between early and late continuous renal replacement therapy groups 9 (2.74) vs. 11 (0.41); p=0.997. Conclusion: Septic patients who developed acute kidney injury and started continuous renal replacement therapy did not showed in any mortality benefit among both groups.Muhammad NasirMadiha HashmiMuhammad SohaibZahoor AhmedMuhammad SalmanSyed Amir RazaArmy Medical College Rawalpindiarticleacute kidney injuryintensive carerenal replacement therapysepsisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 213-218 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury intensive care renal replacement therapy sepsis Medicine R Medicine (General) R5-920
spellingShingle	acute kidney injury intensive care renal replacement therapy sepsis Medicine R Medicine (General) R5-920 Muhammad Nasir Madiha Hashmi Muhammad Sohaib Zahoor Ahmed Muhammad Salman Syed Amir Raza IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
description	Objective: To identify whether the timing of initiation of continuous renal replacement therapy affects outcome in septic patients with acute kidney injury in term of 28 days mortality. Study Design: Cross sectional analytical study. Place and Duration of Study: This research was conducted at department of Anaesthesiology and critical care unit of the Aga Khan University Hospital, Karachi, from Oct 2018 to Jun 2019. Methodology: The study reviewed all adult patients aged >18 years who developed acute kidney injury after septic shock and required continuous renal replacement therapy in surgical intensive care unit. Considering the value of blood urea nitrogen, patients were classified into two groups. One was in early group that‟s was defined as blood urea nitrogen value of <100 mg/dl just before continuous renal replacement therapy initiation while the patients who have blood urea nitrogen value of ≥100 mg/dl just prior to continuous renal replacement therapy initiation were classified as late group. Kaplan-Meier survival analysis was performed and median survival was computed. Results: Forty patients were included for analysis. There were thirty patients (75%) in early group in whom continuous renal replacement therapy was started with mean blood urea nitrogen of 66 ± 20.2 mg/dL and 10 (25%) patients were in late group with mean blood urea nitrogen of 137 ± 28.4 mg/dL. The overall survival rates in both groups were 49.6%, and 10.4% at 10 and 25 days, respectively. Median survival time was not statistically significant between early and late continuous renal replacement therapy groups 9 (2.74) vs. 11 (0.41); p=0.997. Conclusion: Septic patients who developed acute kidney injury and started continuous renal replacement therapy did not showed in any mortality benefit among both groups.
format	article
author	Muhammad Nasir Madiha Hashmi Muhammad Sohaib Zahoor Ahmed Muhammad Salman Syed Amir Raza
author_facet	Muhammad Nasir Madiha Hashmi Muhammad Sohaib Zahoor Ahmed Muhammad Salman Syed Amir Raza
author_sort	Muhammad Nasir
title	IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
title_short	IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
title_full	IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
title_fullStr	IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
title_full_unstemmed	IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS
title_sort	impact of timing of renal replacement therapy initiation on outcome of acute kidney injury in septic patients
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.3450 https://doaj.org/article/4d2c3de7de1c4075880618ff97cd7b37
work_keys_str_mv	AT muhammadnasir impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients AT madihahashmi impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients AT muhammadsohaib impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients AT zahoorahmed impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients AT muhammadsalman impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients AT syedamirraza impactoftimingofrenalreplacementtherapyinitiationonoutcomeofacutekidneyinjuryinsepticpatients
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IMPACT OF TIMING OF RENAL REPLACEMENT THERAPY INITIATION ON OUTCOME OF ACUTE KIDNEY INJURY IN SEPTIC PATIENTS

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