Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis

Background: Recurrent or persistently active sarcoidosis is a risk factor for permanent organ damage. Whether this damage is due to accumulated focal injuries or progressive disease extent is not known, as the natural history of chronic inflammation in sarcoidosis is poorly characterized. The object...

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Autores principales:	Karen C. Patterson, Misha Rosenbach, Paco E. Bravo, Jacob G. Dubroff
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sarcoidosis granuloma cardiac cutaneous chronic recurrence Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4d2e6a4adc654735a57e65cc39072c09
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spelling	oai:doaj.org-article:4d2e6a4adc654735a57e65cc39072c092021-12-03T05:14:43ZStable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis2296-858X10.3389/fmed.2021.729229https://doaj.org/article/4d2e6a4adc654735a57e65cc39072c092021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.729229/fullhttps://doaj.org/toc/2296-858XBackground: Recurrent or persistently active sarcoidosis is a risk factor for permanent organ damage. Whether this damage is due to accumulated focal injuries or progressive disease extent is not known, as the natural history of chronic inflammation in sarcoidosis is poorly characterized. The objective of this study is to determine the pattern of disease in recurrently active sarcoidosis.Methods: We identified patients with recurrent cardiac sarcoidosis (N = 21) retrospectively from an imaging database, and with recurrent cutaneous sarcoidosis (N = 17) from a prospective registry. The longitudinal patterns of cardiac sarcoidosis were established by findings on cardiac positron emission tomography scans, and of cutaneous sarcoidosis by the validated Cutaneous Sarcoidosis Activity and Morphology Instrument clinical scoring system. Patterns of recurrent disease were compared to baseline findings.Results: Recurrent sarcoidosis occurred in a nearly identical pattern and distribution as baseline disease, and spread of disease was rarely observed for both cardiac and cutaneous sarcoidosis: 97% of heart segments positive on recurrence scans were positive on baseline scans, and only one new region of facial disease was observed. In some cases, recurrence followed years of apparent remission.Discussion: Across phenotypes, and across a long period of follow-up, the extent of sarcoidosis was stable in spite of fluctuations in disease activity. For patients with a demonstrated history of recurrent disease affecting critical organs, our findings support the need for long-term follow-up.Karen C. PattersonKaren C. PattersonMisha RosenbachPaco E. BravoPaco E. BravoJacob G. DubroffFrontiers Media S.A.articlesarcoidosisgranulomacardiaccutaneouschronicrecurrenceMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcoidosis granuloma cardiac cutaneous chronic recurrence Medicine (General) R5-920
spellingShingle	sarcoidosis granuloma cardiac cutaneous chronic recurrence Medicine (General) R5-920 Karen C. Patterson Karen C. Patterson Misha Rosenbach Paco E. Bravo Paco E. Bravo Jacob G. Dubroff Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
description	Background: Recurrent or persistently active sarcoidosis is a risk factor for permanent organ damage. Whether this damage is due to accumulated focal injuries or progressive disease extent is not known, as the natural history of chronic inflammation in sarcoidosis is poorly characterized. The objective of this study is to determine the pattern of disease in recurrently active sarcoidosis.Methods: We identified patients with recurrent cardiac sarcoidosis (N = 21) retrospectively from an imaging database, and with recurrent cutaneous sarcoidosis (N = 17) from a prospective registry. The longitudinal patterns of cardiac sarcoidosis were established by findings on cardiac positron emission tomography scans, and of cutaneous sarcoidosis by the validated Cutaneous Sarcoidosis Activity and Morphology Instrument clinical scoring system. Patterns of recurrent disease were compared to baseline findings.Results: Recurrent sarcoidosis occurred in a nearly identical pattern and distribution as baseline disease, and spread of disease was rarely observed for both cardiac and cutaneous sarcoidosis: 97% of heart segments positive on recurrence scans were positive on baseline scans, and only one new region of facial disease was observed. In some cases, recurrence followed years of apparent remission.Discussion: Across phenotypes, and across a long period of follow-up, the extent of sarcoidosis was stable in spite of fluctuations in disease activity. For patients with a demonstrated history of recurrent disease affecting critical organs, our findings support the need for long-term follow-up.
format	article
author	Karen C. Patterson Karen C. Patterson Misha Rosenbach Paco E. Bravo Paco E. Bravo Jacob G. Dubroff
author_facet	Karen C. Patterson Karen C. Patterson Misha Rosenbach Paco E. Bravo Paco E. Bravo Jacob G. Dubroff
author_sort	Karen C. Patterson
title	Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
title_short	Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
title_full	Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
title_fullStr	Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
title_full_unstemmed	Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis
title_sort	stable extent of recurrently active cardiac and cutaneous sarcoidosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4d2e6a4adc654735a57e65cc39072c09
work_keys_str_mv	AT karencpatterson stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis AT karencpatterson stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis AT misharosenbach stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis AT pacoebravo stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis AT pacoebravo stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis AT jacobgdubroff stableextentofrecurrentlyactivecardiacandcutaneoussarcoidosis
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Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis

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