Cognitive impairment in patients with AIDS – prevalence and severity

Cognitive impairment in patients with AIDS – prevalence and severity

Crystal C Watkins,1,2 Glenn J Treisman2 1The Memory Center in Neuropsychiatry, Sheppard Pratt Health System, 2Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The advent of highly active antiretroviral therapy has prolo...

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Autores principales: Watkins CC, Treisman GJ
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/4d2edd8fbb234bf4818a77018079bbea
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spelling oai:doaj.org-article:4d2edd8fbb234bf4818a77018079bbea2021-12-02T02:13:32ZCognitive impairment in patients with AIDS – prevalence and severity1179-1373https://doaj.org/article/4d2edd8fbb234bf4818a77018079bbea2015-01-01T00:00:00Zhttp://www.dovepress.com/cognitive-impairment-in-patients-with-aids-ndash-prevalence-and-severi-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373 Crystal C Watkins,1,2 Glenn J Treisman2 1The Memory Center in Neuropsychiatry, Sheppard Pratt Health System, 2Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The advent of highly active antiretroviral therapy has prolonged the life expectancy of HIV patients and decreased the number of adults who progress to AIDS and HIV-associated dementia. However, neurocognitive deficits remain a pronounced consequence of HIV/AIDS. HIV-1 infection targets the central nervous system in subcortical brain areas and leads to high rates of delirium, depression, opportunistic central nervous system infections, and dementia. Long-term HIV replication in the brain occurs in astrocytes and microglia, allowing the virus to hide from antiviral medication and later compromise neuronal function. The associated cognitive disturbance is linked to both viral activity and inflammatory and other mediators from these immune cells that lead to the damage associated with HIV-associated neurocognitive disorders, a general term given for these disturbances. We review the severity and prevalence of the neuropsychiatric complications of HIV including delirium, neurobehavioral impairments (depression), minor cognitive-motor dysfunction, and HIV-associated dementia. Keywords: HIV, delirium, depression, HAND, dementia; HIV-associated neurocognitive disorderWatkins CCTreisman GJDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2015, Iss default, Pp 35-47 (2015)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
spellingShingle Immunologic diseases. Allergy
RC581-607
Watkins CC
Treisman GJ
Cognitive impairment in patients with AIDS – prevalence and severity
description Crystal C Watkins,1,2 Glenn J Treisman2 1The Memory Center in Neuropsychiatry, Sheppard Pratt Health System, 2Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: The advent of highly active antiretroviral therapy has prolonged the life expectancy of HIV patients and decreased the number of adults who progress to AIDS and HIV-associated dementia. However, neurocognitive deficits remain a pronounced consequence of HIV/AIDS. HIV-1 infection targets the central nervous system in subcortical brain areas and leads to high rates of delirium, depression, opportunistic central nervous system infections, and dementia. Long-term HIV replication in the brain occurs in astrocytes and microglia, allowing the virus to hide from antiviral medication and later compromise neuronal function. The associated cognitive disturbance is linked to both viral activity and inflammatory and other mediators from these immune cells that lead to the damage associated with HIV-associated neurocognitive disorders, a general term given for these disturbances. We review the severity and prevalence of the neuropsychiatric complications of HIV including delirium, neurobehavioral impairments (depression), minor cognitive-motor dysfunction, and HIV-associated dementia. Keywords: HIV, delirium, depression, HAND, dementia; HIV-associated neurocognitive disorder
format article
author Watkins CC
Treisman GJ
author_facet Watkins CC
Treisman GJ
author_sort Watkins CC
title Cognitive impairment in patients with AIDS – prevalence and severity
title_short Cognitive impairment in patients with AIDS – prevalence and severity
title_full Cognitive impairment in patients with AIDS – prevalence and severity
title_fullStr Cognitive impairment in patients with AIDS – prevalence and severity
title_full_unstemmed Cognitive impairment in patients with AIDS – prevalence and severity
title_sort cognitive impairment in patients with aids – prevalence and severity
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/4d2edd8fbb234bf4818a77018079bbea
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