Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinica...

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Autores principales: J. M. Orengo, A. R. Radin, V. Kamat, A. Badithe, L. H. Ben, B. L. Bennett, S. Zhong, D. Birchard, A. Limnander, A. Rafique, J. Bautista, A. Kostic, D. Newell, X. Duan, M. C. Franklin, W. Olson, T. Huang, N. A. Gandhi, L. Lipsich, N. Stahl, N. J. Papadopoulos, A. J. Murphy, G. D. Yancopoulos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/4d30f5e885654cfb894aa83d96ba2276
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Sumario:Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial.

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