Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinica...

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Autores principales: J. M. Orengo, A. R. Radin, V. Kamat, A. Badithe, L. H. Ben, B. L. Bennett, S. Zhong, D. Birchard, A. Limnander, A. Rafique, J. Bautista, A. Kostic, D. Newell, X. Duan, M. C. Franklin, W. Olson, T. Huang, N. A. Gandhi, L. Lipsich, N. Stahl, N. J. Papadopoulos, A. J. Murphy, G. D. Yancopoulos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4d30f5e885654cfb894aa83d96ba2276
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spelling oai:doaj.org-article:4d30f5e885654cfb894aa83d96ba22762021-12-02T16:49:23ZTreating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement10.1038/s41467-018-03636-82041-1723https://doaj.org/article/4d30f5e885654cfb894aa83d96ba22762018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03636-8https://doaj.org/toc/2041-1723Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial.J. M. OrengoA. R. RadinV. KamatA. BaditheL. H. BenB. L. BennettS. ZhongD. BirchardA. LimnanderA. RafiqueJ. BautistaA. KosticD. NewellX. DuanM. C. FranklinW. OlsonT. HuangN. A. GandhiL. LipsichN. StahlN. J. PapadopoulosA. J. MurphyG. D. YancopoulosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
J. M. Orengo
A. R. Radin
V. Kamat
A. Badithe
L. H. Ben
B. L. Bennett
S. Zhong
D. Birchard
A. Limnander
A. Rafique
J. Bautista
A. Kostic
D. Newell
X. Duan
M. C. Franklin
W. Olson
T. Huang
N. A. Gandhi
L. Lipsich
N. Stahl
N. J. Papadopoulos
A. J. Murphy
G. D. Yancopoulos
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
description Allergen-specific immunotherapy is used to treat patients affected by acute immunoglobulin E (IgE) responses, but the function mechanism is unclear. Here the authors show that the administration of two cat allergen-specific IgGs reduces allergic responses in mouse models and helps ameliorate clinical symptoms in a phase 1b clinical trial.
format article
author J. M. Orengo
A. R. Radin
V. Kamat
A. Badithe
L. H. Ben
B. L. Bennett
S. Zhong
D. Birchard
A. Limnander
A. Rafique
J. Bautista
A. Kostic
D. Newell
X. Duan
M. C. Franklin
W. Olson
T. Huang
N. A. Gandhi
L. Lipsich
N. Stahl
N. J. Papadopoulos
A. J. Murphy
G. D. Yancopoulos
author_facet J. M. Orengo
A. R. Radin
V. Kamat
A. Badithe
L. H. Ben
B. L. Bennett
S. Zhong
D. Birchard
A. Limnander
A. Rafique
J. Bautista
A. Kostic
D. Newell
X. Duan
M. C. Franklin
W. Olson
T. Huang
N. A. Gandhi
L. Lipsich
N. Stahl
N. J. Papadopoulos
A. J. Murphy
G. D. Yancopoulos
author_sort J. M. Orengo
title Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
title_short Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
title_full Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
title_fullStr Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
title_full_unstemmed Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement
title_sort treating cat allergy with monoclonal igg antibodies that bind allergen and prevent ige engagement
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4d30f5e885654cfb894aa83d96ba2276
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