A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit

Abstract Modeling long-term neuronal dynamics may require running long-lasting simulations. Such simulations are computationally expensive, and therefore it is advantageous to use simplified models that sufficiently reproduce the real neuronal properties. Reducing the complexity of the neuronal dend...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matus Tomko, Lubica Benuskova, Peter Jedlicka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d3251e2a10e4cfb9c3af9ad4973a680
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4d3251e2a10e4cfb9c3af9ad4973a680
record_format	dspace
spelling	oai:doaj.org-article:4d3251e2a10e4cfb9c3af9ad4973a6802021-12-02T14:26:07ZA new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit10.1038/s41598-021-87002-72045-2322https://doaj.org/article/4d3251e2a10e4cfb9c3af9ad4973a6802021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87002-7https://doaj.org/toc/2045-2322Abstract Modeling long-term neuronal dynamics may require running long-lasting simulations. Such simulations are computationally expensive, and therefore it is advantageous to use simplified models that sufficiently reproduce the real neuronal properties. Reducing the complexity of the neuronal dendritic tree is one option. Therefore, we have developed a new reduced-morphology model of the rat CA1 pyramidal cell which retains major dendritic branch classes. To validate our model with experimental data, we used HippoUnit, a recently established standardized test suite for CA1 pyramidal cell models. The HippoUnit allowed us to systematically evaluate the somatic and dendritic properties of the model and compare them to models publicly available in the ModelDB database. Our model reproduced (1) somatic spiking properties, (2) somatic depolarization block, (3) EPSP attenuation, (4) action potential backpropagation, and (5) synaptic integration at oblique dendrites of CA1 neurons. The overall performance of the model in these tests achieved higher biological accuracy compared to other tested models. We conclude that, due to its realistic biophysics and low morphological complexity, our model captures key physiological features of CA1 pyramidal neurons and shortens computational time, respectively. Thus, the validated reduced-morphology model can be used for computationally demanding simulations as a substitute for more complex models.Matus TomkoLubica BenuskovaPeter JedlickaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matus Tomko Lubica Benuskova Peter Jedlicka A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
description	Abstract Modeling long-term neuronal dynamics may require running long-lasting simulations. Such simulations are computationally expensive, and therefore it is advantageous to use simplified models that sufficiently reproduce the real neuronal properties. Reducing the complexity of the neuronal dendritic tree is one option. Therefore, we have developed a new reduced-morphology model of the rat CA1 pyramidal cell which retains major dendritic branch classes. To validate our model with experimental data, we used HippoUnit, a recently established standardized test suite for CA1 pyramidal cell models. The HippoUnit allowed us to systematically evaluate the somatic and dendritic properties of the model and compare them to models publicly available in the ModelDB database. Our model reproduced (1) somatic spiking properties, (2) somatic depolarization block, (3) EPSP attenuation, (4) action potential backpropagation, and (5) synaptic integration at oblique dendrites of CA1 neurons. The overall performance of the model in these tests achieved higher biological accuracy compared to other tested models. We conclude that, due to its realistic biophysics and low morphological complexity, our model captures key physiological features of CA1 pyramidal neurons and shortens computational time, respectively. Thus, the validated reduced-morphology model can be used for computationally demanding simulations as a substitute for more complex models.
format	article
author	Matus Tomko Lubica Benuskova Peter Jedlicka
author_facet	Matus Tomko Lubica Benuskova Peter Jedlicka
author_sort	Matus Tomko
title	A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
title_short	A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
title_full	A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
title_fullStr	A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
title_full_unstemmed	A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
title_sort	new reduced-morphology model for ca1 pyramidal cells and its validation and comparison with other models using hippounit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d3251e2a10e4cfb9c3af9ad4973a680
work_keys_str_mv	AT matustomko anewreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit AT lubicabenuskova anewreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit AT peterjedlicka anewreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit AT matustomko newreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit AT lubicabenuskova newreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit AT peterjedlicka newreducedmorphologymodelforca1pyramidalcellsanditsvalidationandcomparisonwithothermodelsusinghippounit
_version_	1718391366817415168

A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit

Ejemplares similares