Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach includes an APOE score and a polygenic score exc...

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Autores principales:	Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d36e2473d584250a235b7a2b478f9c3
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spelling	oai:doaj.org-article:4d36e2473d584250a235b7a2b478f9c32021-12-02T16:26:25ZIdentifying individuals with high risk of Alzheimer’s disease using polygenic risk scores10.1038/s41467-021-24082-z2041-1723https://doaj.org/article/4d36e2473d584250a235b7a2b478f9c32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24082-zhttps://doaj.org/toc/2041-1723While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach includes an APOE score and a polygenic score excluding APOE.Ganna LeonenkoEmily BakerJoshua Stevenson-HoareAnnerieke SierksmaMark FiersJulie WilliamsBart de StrooperValentina Escott-PriceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ganna Leonenko Emily Baker Joshua Stevenson-Hoare Annerieke Sierksma Mark Fiers Julie Williams Bart de Strooper Valentina Escott-Price Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
description	While polygenic risk scores have been shown to be correlated with disease risk, there is little agreement on how the score should be calculated. Here the authors investigate risk scores for Alzheimer’s disease, finding that the most effective approach includes an APOE score and a polygenic score excluding APOE.
format	article
author	Ganna Leonenko Emily Baker Joshua Stevenson-Hoare Annerieke Sierksma Mark Fiers Julie Williams Bart de Strooper Valentina Escott-Price
author_facet	Ganna Leonenko Emily Baker Joshua Stevenson-Hoare Annerieke Sierksma Mark Fiers Julie Williams Bart de Strooper Valentina Escott-Price
author_sort	Ganna Leonenko
title	Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
title_short	Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
title_full	Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
title_fullStr	Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
title_full_unstemmed	Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
title_sort	identifying individuals with high risk of alzheimer’s disease using polygenic risk scores
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d36e2473d584250a235b7a2b478f9c3
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Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores

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