Survival of pancreatic cancer cells lacking KRAS function

Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS...

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Autores principales:	Mandar Deepak Muzumdar, Pan-Yu Chen, Kimberly Judith Dorans, Katherine Minjee Chung, Arjun Bhutkar, Erin Hong, Elisa M. Noll, Martin R. Sprick, Andreas Trumpp, Tyler Jacks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d398db26f7f440fbdb14fc260d45e14
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spelling	oai:doaj.org-article:4d398db26f7f440fbdb14fc260d45e142021-12-02T15:38:53ZSurvival of pancreatic cancer cells lacking KRAS function10.1038/s41467-017-00942-52041-1723https://doaj.org/article/4d398db26f7f440fbdb14fc260d45e142017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00942-5https://doaj.org/toc/2041-1723Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.Mandar Deepak MuzumdarPan-Yu ChenKimberly Judith DoransKatherine Minjee ChungArjun BhutkarErin HongElisa M. NollMartin R. SprickAndreas TrumppTyler JacksNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mandar Deepak Muzumdar Pan-Yu Chen Kimberly Judith Dorans Katherine Minjee Chung Arjun Bhutkar Erin Hong Elisa M. Noll Martin R. Sprick Andreas Trumpp Tyler Jacks Survival of pancreatic cancer cells lacking KRAS function
description	Pancreatic cancer cells may develop resistance to KRAS inhibitors due to activation of compensatory pathways. In this study, the authors demonstrate that KRAS is dispensable in a subset of pancreatic cancer and that PI3K signalling may have an important role in mediating tumor growth following KRAS inhibition.
format	article
author	Mandar Deepak Muzumdar Pan-Yu Chen Kimberly Judith Dorans Katherine Minjee Chung Arjun Bhutkar Erin Hong Elisa M. Noll Martin R. Sprick Andreas Trumpp Tyler Jacks
author_facet	Mandar Deepak Muzumdar Pan-Yu Chen Kimberly Judith Dorans Katherine Minjee Chung Arjun Bhutkar Erin Hong Elisa M. Noll Martin R. Sprick Andreas Trumpp Tyler Jacks
author_sort	Mandar Deepak Muzumdar
title	Survival of pancreatic cancer cells lacking KRAS function
title_short	Survival of pancreatic cancer cells lacking KRAS function
title_full	Survival of pancreatic cancer cells lacking KRAS function
title_fullStr	Survival of pancreatic cancer cells lacking KRAS function
title_full_unstemmed	Survival of pancreatic cancer cells lacking KRAS function
title_sort	survival of pancreatic cancer cells lacking kras function
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4d398db26f7f440fbdb14fc260d45e14
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Survival of pancreatic cancer cells lacking KRAS function

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