Mapping the mutual information network of enzymatic families in the protein structure to unveil functional features.

Amino acids committed to a particular function correlate tightly along evolution and tend to form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a network of co-evolving clusters of residues. The goal of this work is two-fold: first, we have combined mutual infor...

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Autores principales: Daniel Aguilar, Baldo Oliva, Cristina Marino Buslje
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/4d3c88af5d6e46cf9c3da22ca133298f
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