Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.

<h4>Background</h4>No reliable biomarkers are identified in KLS. However, few functional neuroimaging studies suggested hypoactivity in thalamic and hypothalamic regions during symptomatic episodes. Here, we investigated relative changes in regional brain metabolism in Kleine-Levin syndr...

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Autores principales:	Yves Dauvilliers, Sophie Bayard, Régis Lopez, Frederic Comte, Michel Zanca, Philippe Peigneux
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d3cac2508f14cf59af76b1d09edc123
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spelling	oai:doaj.org-article:4d3cac2508f14cf59af76b1d09edc1232021-11-18T08:25:00ZWidespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.1932-620310.1371/journal.pone.0093813https://doaj.org/article/4d3cac2508f14cf59af76b1d09edc1232014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24699677/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>No reliable biomarkers are identified in KLS. However, few functional neuroimaging studies suggested hypoactivity in thalamic and hypothalamic regions during symptomatic episodes. Here, we investigated relative changes in regional brain metabolism in Kleine-Levin syndrome (KLS) during symptomatic episodes and asymptomatic periods, as compared to healthy controls.<h4>Methods</h4>Four drug-free male patients with typical KLS and 15 healthy controls were included. 18-F-fluorodeoxy glucose positron emission tomography (PET) was obtained in baseline condition in all participants, and during symptomatic episodes in KLS patients. All participants were asked to remain fully awake during the whole PET procedure.<h4>Results</h4>Between state-comparisons in KLS disclosed higher metabolism in paracentral, precentral, and postcentral areas, supplementary motor area, medial frontal gyrus, thalamus and putamen during symptomatic episodes, and decreased metabolism in occipital and temporal gyri. As compared to healthy control subjects, KLS patients in the asymptomatic phase consistently exhibited significant hypermetabolism in a wide cortical network including frontal and temporal cortices, posterior cingulate and precuneus, with no detected hypometabolism. In symptomatic KLS episodes, hypermetabolism was additionally found in orbital frontal and supplementary motor areas, insula and inferior parietal areas, and right caudate nucleus, and hypometabolism in the middle occipital gyrus and inferior parietal areas.<h4>Conclusion</h4>Our results demonstrated significant hypermetabolism and few hypometabolism in specific but widespread brain regions in drug-free KLS patients at baseline and during symptomatic episodes, highlighting the behavioral state-dependent nature of changes in regional brain activity in KLS.Yves DauvilliersSophie BayardRégis LopezFrederic ComteMichel ZancaPhilippe PeigneuxPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e93813 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yves Dauvilliers Sophie Bayard Régis Lopez Frederic Comte Michel Zanca Philippe Peigneux Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
description	<h4>Background</h4>No reliable biomarkers are identified in KLS. However, few functional neuroimaging studies suggested hypoactivity in thalamic and hypothalamic regions during symptomatic episodes. Here, we investigated relative changes in regional brain metabolism in Kleine-Levin syndrome (KLS) during symptomatic episodes and asymptomatic periods, as compared to healthy controls.<h4>Methods</h4>Four drug-free male patients with typical KLS and 15 healthy controls were included. 18-F-fluorodeoxy glucose positron emission tomography (PET) was obtained in baseline condition in all participants, and during symptomatic episodes in KLS patients. All participants were asked to remain fully awake during the whole PET procedure.<h4>Results</h4>Between state-comparisons in KLS disclosed higher metabolism in paracentral, precentral, and postcentral areas, supplementary motor area, medial frontal gyrus, thalamus and putamen during symptomatic episodes, and decreased metabolism in occipital and temporal gyri. As compared to healthy control subjects, KLS patients in the asymptomatic phase consistently exhibited significant hypermetabolism in a wide cortical network including frontal and temporal cortices, posterior cingulate and precuneus, with no detected hypometabolism. In symptomatic KLS episodes, hypermetabolism was additionally found in orbital frontal and supplementary motor areas, insula and inferior parietal areas, and right caudate nucleus, and hypometabolism in the middle occipital gyrus and inferior parietal areas.<h4>Conclusion</h4>Our results demonstrated significant hypermetabolism and few hypometabolism in specific but widespread brain regions in drug-free KLS patients at baseline and during symptomatic episodes, highlighting the behavioral state-dependent nature of changes in regional brain activity in KLS.
format	article
author	Yves Dauvilliers Sophie Bayard Régis Lopez Frederic Comte Michel Zanca Philippe Peigneux
author_facet	Yves Dauvilliers Sophie Bayard Régis Lopez Frederic Comte Michel Zanca Philippe Peigneux
author_sort	Yves Dauvilliers
title	Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
title_short	Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
title_full	Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
title_fullStr	Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
title_full_unstemmed	Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.
title_sort	widespread hypermetabolism in symptomatic and asymptomatic episodes in kleine-levin syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/4d3cac2508f14cf59af76b1d09edc123
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Widespread hypermetabolism in symptomatic and asymptomatic episodes in Kleine-Levin syndrome.

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