Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes

Spirocycles are traditionally difficult structures to synthesize due to the congested nature of the central atom. Here the authors show a method to synthesize quaternary carbon spirocycles in one step from 1,3-enynes and pyrazolidine-type heterocycles, both relatively unactivated structures, proceed...

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Autores principales:	Long Li, Shan Wang, Pengfei Luo, Ran Wang, Zheng Wang, Xiaoguang Li, Yuhua Deng, Fangzhi Peng, Zhihui Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d3eba8180b049f1b3931c209daf7c4b
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spelling	oai:doaj.org-article:4d3eba8180b049f1b3931c209daf7c4b2021-12-02T17:18:32ZDirect access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes10.1038/s41467-021-25981-x2041-1723https://doaj.org/article/4d3eba8180b049f1b3931c209daf7c4b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25981-xhttps://doaj.org/toc/2041-1723Spirocycles are traditionally difficult structures to synthesize due to the congested nature of the central atom. Here the authors show a method to synthesize quaternary carbon spirocycles in one step from 1,3-enynes and pyrazolidine-type heterocycles, both relatively unactivated structures, proceeding via palladium catalysis.Long LiShan WangPengfei LuoRan WangZheng WangXiaoguang LiYuhua DengFangzhi PengZhihui ShaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Long Li Shan Wang Pengfei Luo Ran Wang Zheng Wang Xiaoguang Li Yuhua Deng Fangzhi Peng Zhihui Shao Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
description	Spirocycles are traditionally difficult structures to synthesize due to the congested nature of the central atom. Here the authors show a method to synthesize quaternary carbon spirocycles in one step from 1,3-enynes and pyrazolidine-type heterocycles, both relatively unactivated structures, proceeding via palladium catalysis.
format	article
author	Long Li Shan Wang Pengfei Luo Ran Wang Zheng Wang Xiaoguang Li Yuhua Deng Fangzhi Peng Zhihui Shao
author_facet	Long Li Shan Wang Pengfei Luo Ran Wang Zheng Wang Xiaoguang Li Yuhua Deng Fangzhi Peng Zhihui Shao
author_sort	Long Li
title	Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
title_short	Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
title_full	Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
title_fullStr	Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
title_full_unstemmed	Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes
title_sort	direct access to spirocycles by pd/wingphos-catalyzed enantioselective cycloaddition of 1,3-enynes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d3eba8180b049f1b3931c209daf7c4b
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Direct access to spirocycles by Pd/WingPhos-catalyzed enantioselective cycloaddition of 1,3-enynes

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