The mTOR pathway is necessary for survival of mice with short telomeres

Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.

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Autores principales:	Iole Ferrara-Romeo, Paula Martinez, Sarita Saraswati, Kurt Whittemore, Osvaldo Graña-Castro, Lydia Thelma Poluha, Rosa Serrano, Elena Hernandez-Encinas, Carmen Blanco-Aparicio, Juana Maria Flores, Maria A. Blasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d4074052eef403bb59da8eb2a97f7ad
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spelling	oai:doaj.org-article:4d4074052eef403bb59da8eb2a97f7ad2021-12-02T17:32:13ZThe mTOR pathway is necessary for survival of mice with short telomeres10.1038/s41467-020-14962-12041-1723https://doaj.org/article/4d4074052eef403bb59da8eb2a97f7ad2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14962-1https://doaj.org/toc/2041-1723Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.Iole Ferrara-RomeoPaula MartinezSarita SaraswatiKurt WhittemoreOsvaldo Graña-CastroLydia Thelma PoluhaRosa SerranoElena Hernandez-EncinasCarmen Blanco-AparicioJuana Maria FloresMaria A. BlascoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iole Ferrara-Romeo Paula Martinez Sarita Saraswati Kurt Whittemore Osvaldo Graña-Castro Lydia Thelma Poluha Rosa Serrano Elena Hernandez-Encinas Carmen Blanco-Aparicio Juana Maria Flores Maria A. Blasco The mTOR pathway is necessary for survival of mice with short telomeres
description	Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.
format	article
author	Iole Ferrara-Romeo Paula Martinez Sarita Saraswati Kurt Whittemore Osvaldo Graña-Castro Lydia Thelma Poluha Rosa Serrano Elena Hernandez-Encinas Carmen Blanco-Aparicio Juana Maria Flores Maria A. Blasco
author_facet	Iole Ferrara-Romeo Paula Martinez Sarita Saraswati Kurt Whittemore Osvaldo Graña-Castro Lydia Thelma Poluha Rosa Serrano Elena Hernandez-Encinas Carmen Blanco-Aparicio Juana Maria Flores Maria A. Blasco
author_sort	Iole Ferrara-Romeo
title	The mTOR pathway is necessary for survival of mice with short telomeres
title_short	The mTOR pathway is necessary for survival of mice with short telomeres
title_full	The mTOR pathway is necessary for survival of mice with short telomeres
title_fullStr	The mTOR pathway is necessary for survival of mice with short telomeres
title_full_unstemmed	The mTOR pathway is necessary for survival of mice with short telomeres
title_sort	mtor pathway is necessary for survival of mice with short telomeres
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4d4074052eef403bb59da8eb2a97f7ad
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The mTOR pathway is necessary for survival of mice with short telomeres

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