Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories

Toxicity and limited solubility inhibits the biological production of many organic compounds. Here the authors metabolically engineer sulfate uptake and activation in order to produce sulfate esters of phenolic compounds, such as zosteric acid, thereby addressing these issues.

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Autores principales: Christian Bille Jendresen, Alex Toftgaard Nielsen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4d40893c73e04afca88245dc6f05483d
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spelling oai:doaj.org-article:4d40893c73e04afca88245dc6f05483d2021-12-02T16:57:50ZProduction of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories10.1038/s41467-019-12022-x2041-1723https://doaj.org/article/4d40893c73e04afca88245dc6f05483d2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12022-xhttps://doaj.org/toc/2041-1723Toxicity and limited solubility inhibits the biological production of many organic compounds. Here the authors metabolically engineer sulfate uptake and activation in order to produce sulfate esters of phenolic compounds, such as zosteric acid, thereby addressing these issues.Christian Bille JendresenAlex Toftgaard NielsenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christian Bille Jendresen
Alex Toftgaard Nielsen
Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
description Toxicity and limited solubility inhibits the biological production of many organic compounds. Here the authors metabolically engineer sulfate uptake and activation in order to produce sulfate esters of phenolic compounds, such as zosteric acid, thereby addressing these issues.
format article
author Christian Bille Jendresen
Alex Toftgaard Nielsen
author_facet Christian Bille Jendresen
Alex Toftgaard Nielsen
author_sort Christian Bille Jendresen
title Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
title_short Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
title_full Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
title_fullStr Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
title_full_unstemmed Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
title_sort production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4d40893c73e04afca88245dc6f05483d
work_keys_str_mv AT christianbillejendresen productionofzostericacidandothersulfatedphenolicbiochemicalsinmicrobialcellfactories
AT alextoftgaardnielsen productionofzostericacidandothersulfatedphenolicbiochemicalsinmicrobialcellfactories
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