iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer

The therapeutic efficacy of adoptive T cell transfer is limited by their ability to infiltrate solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell surface of T cells enhances their ability to penetrate the tumour, resulting in enhanced efficacy in...

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Autores principales:	Naiqing Ding, Zhengyun Zou, Huizi Sha, Shu Su, Hanqing Qian, Fanyan Meng, Fangjun Chen, Shiyao Du, Shujuan Zhou, Hong Chen, Lianru Zhang, Ju Yang, Jia Wei, Baorui Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d424ce982544f98bbf28d7feda3ba49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:4d424ce982544f98bbf28d7feda3ba492021-12-02T16:57:53ZiRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer10.1038/s41467-019-09296-62041-1723https://doaj.org/article/4d424ce982544f98bbf28d7feda3ba492019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09296-6https://doaj.org/toc/2041-1723The therapeutic efficacy of adoptive T cell transfer is limited by their ability to infiltrate solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell surface of T cells enhances their ability to penetrate the tumour, resulting in enhanced efficacy in a mouse model of gastric cancer.Naiqing DingZhengyun ZouHuizi ShaShu SuHanqing QianFanyan MengFangjun ChenShiyao DuShujuan ZhouHong ChenLianru ZhangJu YangJia WeiBaorui LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naiqing Ding Zhengyun Zou Huizi Sha Shu Su Hanqing Qian Fanyan Meng Fangjun Chen Shiyao Du Shujuan Zhou Hong Chen Lianru Zhang Ju Yang Jia Wei Baorui Liu iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
description	The therapeutic efficacy of adoptive T cell transfer is limited by their ability to infiltrate solid tumours. Here, the authors show that loading the tumor penetrating cyclic peptide iRGD on the cell surface of T cells enhances their ability to penetrate the tumour, resulting in enhanced efficacy in a mouse model of gastric cancer.
format	article
author	Naiqing Ding Zhengyun Zou Huizi Sha Shu Su Hanqing Qian Fanyan Meng Fangjun Chen Shiyao Du Shujuan Zhou Hong Chen Lianru Zhang Ju Yang Jia Wei Baorui Liu
author_facet	Naiqing Ding Zhengyun Zou Huizi Sha Shu Su Hanqing Qian Fanyan Meng Fangjun Chen Shiyao Du Shujuan Zhou Hong Chen Lianru Zhang Ju Yang Jia Wei Baorui Liu
author_sort	Naiqing Ding
title	iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
title_short	iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
title_full	iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
title_fullStr	iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
title_full_unstemmed	iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
title_sort	irgd synergizes with pd-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4d424ce982544f98bbf28d7feda3ba49
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iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer

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