Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two...

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Autores principales:	Yu Gao, Hongmei Zhang, Minrui Fan, Chenjun Jia, Lifang Shi, Xiaowei Pan, Peng Cao, Xuelin Zhao, Wenrui Chang, Mei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d445b2697784e0299c791b5b23c01c6
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spelling	oai:doaj.org-article:4d445b2697784e0299c791b5b23c01c62021-12-02T17:32:26ZStructural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase10.1038/s41467-020-15268-y2041-1723https://doaj.org/article/4d445b2697784e0299c791b5b23c01c62020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15268-yhttps://doaj.org/toc/2041-1723Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two enzymes by determining the crystal structures of AAR alone and three AAR–ADO complexes with various bound ligands.Yu GaoHongmei ZhangMinrui FanChenjun JiaLifang ShiXiaowei PanPeng CaoXuelin ZhaoWenrui ChangMei LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Gao Hongmei Zhang Minrui Fan Chenjun Jia Lifang Shi Xiaowei Pan Peng Cao Xuelin Zhao Wenrui Chang Mei Li Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
description	Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two enzymes by determining the crystal structures of AAR alone and three AAR–ADO complexes with various bound ligands.
format	article
author	Yu Gao Hongmei Zhang Minrui Fan Chenjun Jia Lifang Shi Xiaowei Pan Peng Cao Xuelin Zhao Wenrui Chang Mei Li
author_facet	Yu Gao Hongmei Zhang Minrui Fan Chenjun Jia Lifang Shi Xiaowei Pan Peng Cao Xuelin Zhao Wenrui Chang Mei Li
author_sort	Yu Gao
title	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
title_short	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
title_full	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
title_fullStr	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
title_full_unstemmed	Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
title_sort	structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4d445b2697784e0299c791b5b23c01c6
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Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase

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