Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?

Metal complexes based on transition metals have rich photochemical and photophysical properties that are derived from a variety of excited state electronic configurations triggered by visible and near-infrared light. These properties can be exploited to produce powerful energy and electron transfer...

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Autores principales:	Alain C. Jung, Fabien Moinard-Butot, Chloé Thibaudeau, Gilles Gasser, Christian Gaiddon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer photodynamic therapy transition metals immunogenic cell death Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4d47f3e6afdc4f6f9035d0ce13af5040
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spelling	oai:doaj.org-article:4d47f3e6afdc4f6f9035d0ce13af50402021-11-25T18:40:41ZAntitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?10.3390/pharmaceutics131117881999-4923https://doaj.org/article/4d47f3e6afdc4f6f9035d0ce13af50402021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1788https://doaj.org/toc/1999-4923Metal complexes based on transition metals have rich photochemical and photophysical properties that are derived from a variety of excited state electronic configurations triggered by visible and near-infrared light. These properties can be exploited to produce powerful energy and electron transfer processes that can lead to oxygen-(in)dependent photobiological activity. These principles are the basis of photodynamic therapy (PDT), which is a clinically approved treatment that offers a promising, effective, and noninvasive complementary treatment or even an alternative to treat several types of cancers. PDT is based on a reaction involving a photosensitizer (PS), light, and oxygen, which ultimately generates cytotoxic reactive oxygen species (ROS). However, skin photosensitivity, due to the accumulation of PSs in skin cells, has hampered, among other elements, its clinical development and application. Therefore, these is an increasing interest in the use of (metal-based) PSs that are more specific to tumor cells. This may increase efficacy and corollary decrease side-effects. To this end, metal-containing nanoparticles with photosensitizing properties have recently been developed. In addition, several studies have reported that the use of immunogenic/immunomodulatory metal-based nanoparticles increases the antitumor efficacy of immune-checkpoint inhibitor-based immunotherapy mediated by anti-PD-(L)1 or CTLA-4 antibodies. In this review, we discuss the main metal complexes used as PDT PSs. Lastly, we review the preclinical studies associated with metal-based PDT PSs and immunotherapies. This therapeutic association could stimulate PDT.Alain C. JungFabien Moinard-ButotChloé ThibaudeauGilles GasserChristian GaiddonMDPI AGarticlecancerphotodynamic therapytransition metalsimmunogenic cell deathPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1788, p 1788 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer photodynamic therapy transition metals immunogenic cell death Pharmacy and materia medica RS1-441
spellingShingle	cancer photodynamic therapy transition metals immunogenic cell death Pharmacy and materia medica RS1-441 Alain C. Jung Fabien Moinard-Butot Chloé Thibaudeau Gilles Gasser Christian Gaiddon Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
description	Metal complexes based on transition metals have rich photochemical and photophysical properties that are derived from a variety of excited state electronic configurations triggered by visible and near-infrared light. These properties can be exploited to produce powerful energy and electron transfer processes that can lead to oxygen-(in)dependent photobiological activity. These principles are the basis of photodynamic therapy (PDT), which is a clinically approved treatment that offers a promising, effective, and noninvasive complementary treatment or even an alternative to treat several types of cancers. PDT is based on a reaction involving a photosensitizer (PS), light, and oxygen, which ultimately generates cytotoxic reactive oxygen species (ROS). However, skin photosensitivity, due to the accumulation of PSs in skin cells, has hampered, among other elements, its clinical development and application. Therefore, these is an increasing interest in the use of (metal-based) PSs that are more specific to tumor cells. This may increase efficacy and corollary decrease side-effects. To this end, metal-containing nanoparticles with photosensitizing properties have recently been developed. In addition, several studies have reported that the use of immunogenic/immunomodulatory metal-based nanoparticles increases the antitumor efficacy of immune-checkpoint inhibitor-based immunotherapy mediated by anti-PD-(L)1 or CTLA-4 antibodies. In this review, we discuss the main metal complexes used as PDT PSs. Lastly, we review the preclinical studies associated with metal-based PDT PSs and immunotherapies. This therapeutic association could stimulate PDT.
format	article
author	Alain C. Jung Fabien Moinard-Butot Chloé Thibaudeau Gilles Gasser Christian Gaiddon
author_facet	Alain C. Jung Fabien Moinard-Butot Chloé Thibaudeau Gilles Gasser Christian Gaiddon
author_sort	Alain C. Jung
title	Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
title_short	Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
title_full	Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
title_fullStr	Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
title_full_unstemmed	Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?
title_sort	antitumor immune response triggered by metal-based photosensitizers for photodynamic therapy: where are we?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4d47f3e6afdc4f6f9035d0ce13af5040
work_keys_str_mv	AT alaincjung antitumorimmuneresponsetriggeredbymetalbasedphotosensitizersforphotodynamictherapywherearewe AT fabienmoinardbutot antitumorimmuneresponsetriggeredbymetalbasedphotosensitizersforphotodynamictherapywherearewe AT chloethibaudeau antitumorimmuneresponsetriggeredbymetalbasedphotosensitizersforphotodynamictherapywherearewe AT gillesgasser antitumorimmuneresponsetriggeredbymetalbasedphotosensitizersforphotodynamictherapywherearewe AT christiangaiddon antitumorimmuneresponsetriggeredbymetalbasedphotosensitizersforphotodynamictherapywherearewe
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Antitumor Immune Response Triggered by Metal-Based Photosensitizers for Photodynamic Therapy: Where Are We?

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