Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?

ABSTRACT The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of th...

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Autores principales:	Clara Maria Ausiello, Antonio Cassone
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4d47fd2e6b014bc3be41b87e1d521fab
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spelling	oai:doaj.org-article:4d47fd2e6b014bc3be41b87e1d521fab2021-11-15T15:47:39ZAcellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?10.1128/mBio.01339-142150-7511https://doaj.org/article/4d47fd2e6b014bc3be41b87e1d521fab2014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01339-14https://doaj.org/toc/2150-7511ABSTRACT The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of limited antigenic composition and early waning of antibody levels could be anticipated by the results of in-trial or postlicensure human investigations of B- and T-cell responses in aP versus wP vaccine recipients or unvaccinated, infected children. Recent data in experimental models, including primates, suggest that generation of vaccines capable of a potent, though regulated, stimulation of innate immunity driving effective, persistent adaptive immune responses against Bordetella pertussis infection should be privileged. Adjuvants that skew Th1/Th17 responses or new wP (detoxified or attenuated) vaccines should be explored. Nonetheless, the high merits of the current aP vaccines in persuading people to resume vaccination against pertussis should not be forgotten.Clara Maria AusielloAntonio CassoneAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Clara Maria Ausiello Antonio Cassone Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
description	ABSTRACT The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of limited antigenic composition and early waning of antibody levels could be anticipated by the results of in-trial or postlicensure human investigations of B- and T-cell responses in aP versus wP vaccine recipients or unvaccinated, infected children. Recent data in experimental models, including primates, suggest that generation of vaccines capable of a potent, though regulated, stimulation of innate immunity driving effective, persistent adaptive immune responses against Bordetella pertussis infection should be privileged. Adjuvants that skew Th1/Th17 responses or new wP (detoxified or attenuated) vaccines should be explored. Nonetheless, the high merits of the current aP vaccines in persuading people to resume vaccination against pertussis should not be forgotten.
format	article
author	Clara Maria Ausiello Antonio Cassone
author_facet	Clara Maria Ausiello Antonio Cassone
author_sort	Clara Maria Ausiello
title	Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
title_short	Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
title_full	Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
title_fullStr	Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
title_full_unstemmed	Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?
title_sort	acellular pertussis vaccines and pertussis resurgence: revise or replace?
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/4d47fd2e6b014bc3be41b87e1d521fab
work_keys_str_mv	AT claramariaausiello acellularpertussisvaccinesandpertussisresurgencereviseorreplace AT antoniocassone acellularpertussisvaccinesandpertussisresurgencereviseorreplace
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Acellular Pertussis Vaccines and Pertussis Resurgence: Revise or Replace?

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