Oxidative stress parameters as biomarkers of bladder cancer development and progression

Abstract The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common ty...

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Autores principales:	Paulina Wigner, Beata Szymańska, Michał Bijak, Ewa Sawicka, Paweł Kowal, Zofia Marchewka, Joanna Saluk-Bijak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4d4faa01bc8040c2b669954e3753ce7c
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spelling	oai:doaj.org-article:4d4faa01bc8040c2b669954e3753ce7c2021-12-02T16:17:17ZOxidative stress parameters as biomarkers of bladder cancer development and progression10.1038/s41598-021-94729-w2045-2322https://doaj.org/article/4d4faa01bc8040c2b669954e3753ce7c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94729-whttps://doaj.org/toc/2045-2322Abstract The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common type of cancer all over the world, there is little evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Our study aimed to investigate the plasma levels of typical markers of oxidative/nitrative stress depending on the clinical classification of bladder cancer differentiation and infiltration degree. We examined 40 patients with newly diagnosed bladder cancer and 20 healthy volunteers as a control group. We analysed the plasma levels of protein carbonyls, thiol groups, 3-nitrotyrosine, lipid peroxidation, as well as non-enzymatic plasma antioxidant capacity using DPPH · and ABTS ·+ radicals. We confirmed that all analysed biomarkers are higher in enrolled BC patients than in healthy subjects. Furthermore, our findings demonstrate a positive correlation between the degree of bladder cancer progression and the level of oxidative stress, but no correlation in the case of NT-3. Based on obtained results, we might conclude that during carcinogenesis of the bladder increased oxidative damage of biomolecules is manifested. This indicates the participation of oxidative stress in the development of bladder cancer, and it is important the ensure the proper antioxidant protection.Paulina WignerBeata SzymańskaMichał BijakEwa SawickaPaweł KowalZofia MarchewkaJoanna Saluk-BijakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paulina Wigner Beata Szymańska Michał Bijak Ewa Sawicka Paweł Kowal Zofia Marchewka Joanna Saluk-Bijak Oxidative stress parameters as biomarkers of bladder cancer development and progression
description	Abstract The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common type of cancer all over the world, there is little evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Our study aimed to investigate the plasma levels of typical markers of oxidative/nitrative stress depending on the clinical classification of bladder cancer differentiation and infiltration degree. We examined 40 patients with newly diagnosed bladder cancer and 20 healthy volunteers as a control group. We analysed the plasma levels of protein carbonyls, thiol groups, 3-nitrotyrosine, lipid peroxidation, as well as non-enzymatic plasma antioxidant capacity using DPPH · and ABTS ·+ radicals. We confirmed that all analysed biomarkers are higher in enrolled BC patients than in healthy subjects. Furthermore, our findings demonstrate a positive correlation between the degree of bladder cancer progression and the level of oxidative stress, but no correlation in the case of NT-3. Based on obtained results, we might conclude that during carcinogenesis of the bladder increased oxidative damage of biomolecules is manifested. This indicates the participation of oxidative stress in the development of bladder cancer, and it is important the ensure the proper antioxidant protection.
format	article
author	Paulina Wigner Beata Szymańska Michał Bijak Ewa Sawicka Paweł Kowal Zofia Marchewka Joanna Saluk-Bijak
author_facet	Paulina Wigner Beata Szymańska Michał Bijak Ewa Sawicka Paweł Kowal Zofia Marchewka Joanna Saluk-Bijak
author_sort	Paulina Wigner
title	Oxidative stress parameters as biomarkers of bladder cancer development and progression
title_short	Oxidative stress parameters as biomarkers of bladder cancer development and progression
title_full	Oxidative stress parameters as biomarkers of bladder cancer development and progression
title_fullStr	Oxidative stress parameters as biomarkers of bladder cancer development and progression
title_full_unstemmed	Oxidative stress parameters as biomarkers of bladder cancer development and progression
title_sort	oxidative stress parameters as biomarkers of bladder cancer development and progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4d4faa01bc8040c2b669954e3753ce7c
work_keys_str_mv	AT paulinawigner oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT beataszymanska oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT michałbijak oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT ewasawicka oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT pawełkowal oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT zofiamarchewka oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression AT joannasalukbijak oxidativestressparametersasbiomarkersofbladdercancerdevelopmentandprogression
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Oxidative stress parameters as biomarkers of bladder cancer development and progression

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