Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model

Changping Dun,1 Junqian Liu,1 Fucheng Qiu,1 Xueda Wu,2 Yakun Wang,3 Yongyan Zhao,4 Ping Gu1 1Department of Neurology, the First Hospital of Hebei Medical University, 2Department of Cardiac Surgery, the Second Hospital of Hebei Medical University, 3Department of Endocrinology, the Fourth Hospital of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dun C, Liu J, Qiu F, Wu X, Wang Y, Zhao Y, Gu P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Diabetic astragalus polysaccharides memory impairment MDA SOD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4d519befc7b4463abc023ac8943b9c68
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4d519befc7b4463abc023ac8943b9c68
record_format	dspace
spelling	oai:doaj.org-article:4d519befc7b4463abc023ac8943b9c682021-12-02T03:07:22ZEffects of Astragalus polysaccharides on memory impairment in a diabetic rat model1178-2021https://doaj.org/article/4d519befc7b4463abc023ac8943b9c682016-07-01T00:00:00Zhttps://www.dovepress.com/effects-of-astragalus-polysaccharides-on-memory-impairment-in-a-diabet-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Changping Dun,1 Junqian Liu,1 Fucheng Qiu,1 Xueda Wu,2 Yakun Wang,3 Yongyan Zhao,4 Ping Gu1 1Department of Neurology, the First Hospital of Hebei Medical University, 2Department of Cardiac Surgery, the Second Hospital of Hebei Medical University, 3Department of Endocrinology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 4Department of Nursing, Maternal and Child Health Hospital of Tangshan City, Tangshan, People’s Republic of China Objective: Astragalus polysaccharides (APS) are active constituents of Astragalus membranaceus. In this study, we aimed to investigate the effects of APS on memory impairment in a diabetic rat model and their mechanisms. Methods: A diabetic model was established in 50 male Wistar rats with streptozotocin intraperitoneal injection. A blood glucose level higher than 16.7 mmol/L obtained 72 hours after the injection was regarded as a successful diabetic model. The modeled rats were divided into model group, high, medium, and low doses of APS, and piracetam groups (positive control). A group of ten rats without streptozotocin-induced diabetes were used as a normal control. After respective consecutive 8-week treatments, the levels of blood fasting plasma glucose, insulin, hemoglobin A1c, memory performance, hippocampal malondialdehyde, and superoxide dismutase were determined. Results: After the 8-week APS treatment, serum fasting plasma glucose, hemoglobin A1c, and insulin levels were decreased compared with those of the model group (P<0.05). Importantly, memory impairment in the diabetic model was reversed by APS treatments. In addition, hippocampal malondialdehyde concentration was lowered, whereas that of superoxide dismutase was higher after APS treatments. Conclusion: APS are important active components responsible for memory improvement in rats with streptozotocin-induced diabetes. The potential mechanism of action is associated with the effects of APS on glucose and lipid metabolism, and antioxidative and insulin resistance. APS are constituents of A. membranaceus that are potential candidate therapeutic agents for the treatment of memory deficit in diabetes. Keywords: diabetic, Astragalus polysaccharides, memory impairment, MDA, SODDun CLiu JQiu FWu XWang YZhao YGu PDove Medical PressarticleDiabeticastragalus polysaccharidesmemory impairmentMDASODNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1617-1621 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetic astragalus polysaccharides memory impairment MDA SOD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Diabetic astragalus polysaccharides memory impairment MDA SOD Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dun C Liu J Qiu F Wu X Wang Y Zhao Y Gu P Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
description	Changping Dun,1 Junqian Liu,1 Fucheng Qiu,1 Xueda Wu,2 Yakun Wang,3 Yongyan Zhao,4 Ping Gu1 1Department of Neurology, the First Hospital of Hebei Medical University, 2Department of Cardiac Surgery, the Second Hospital of Hebei Medical University, 3Department of Endocrinology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, 4Department of Nursing, Maternal and Child Health Hospital of Tangshan City, Tangshan, People’s Republic of China Objective: Astragalus polysaccharides (APS) are active constituents of Astragalus membranaceus. In this study, we aimed to investigate the effects of APS on memory impairment in a diabetic rat model and their mechanisms. Methods: A diabetic model was established in 50 male Wistar rats with streptozotocin intraperitoneal injection. A blood glucose level higher than 16.7 mmol/L obtained 72 hours after the injection was regarded as a successful diabetic model. The modeled rats were divided into model group, high, medium, and low doses of APS, and piracetam groups (positive control). A group of ten rats without streptozotocin-induced diabetes were used as a normal control. After respective consecutive 8-week treatments, the levels of blood fasting plasma glucose, insulin, hemoglobin A1c, memory performance, hippocampal malondialdehyde, and superoxide dismutase were determined. Results: After the 8-week APS treatment, serum fasting plasma glucose, hemoglobin A1c, and insulin levels were decreased compared with those of the model group (P<0.05). Importantly, memory impairment in the diabetic model was reversed by APS treatments. In addition, hippocampal malondialdehyde concentration was lowered, whereas that of superoxide dismutase was higher after APS treatments. Conclusion: APS are important active components responsible for memory improvement in rats with streptozotocin-induced diabetes. The potential mechanism of action is associated with the effects of APS on glucose and lipid metabolism, and antioxidative and insulin resistance. APS are constituents of A. membranaceus that are potential candidate therapeutic agents for the treatment of memory deficit in diabetes. Keywords: diabetic, Astragalus polysaccharides, memory impairment, MDA, SOD
format	article
author	Dun C Liu J Qiu F Wu X Wang Y Zhao Y Gu P
author_facet	Dun C Liu J Qiu F Wu X Wang Y Zhao Y Gu P
author_sort	Dun C
title	Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
title_short	Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
title_full	Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
title_fullStr	Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
title_full_unstemmed	Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model
title_sort	effects of astragalus polysaccharides on memory impairment in a diabetic rat model
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4d519befc7b4463abc023ac8943b9c68
work_keys_str_mv	AT dunc effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT liuj effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT qiuf effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT wux effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT wangy effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT zhaoy effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel AT gup effectsofastragaluspolysaccharidesonmemoryimpairmentinadiabeticratmodel
_version_	1718401914993901568

Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model

Ejemplares similares